Phenylguanine found in urine after benzene exposure.

Comparative investigations with synthetic N7-phenylguanine were carried out to clarify whether this compound is eliminated via the urine of rats as a benzene-derived nucleic acid adduct. As sensitive methods for detecting trace amounts of the compound, gas chromatography-mass spectroscopy, high perf...

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Detalles Bibliográficos
Autores principales: Norpoth, K H, Müller, G, Schell, C, Jorg, E
Formato: Texto
Lenguaje:English
Publicado: 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469737/
https://www.ncbi.nlm.nih.gov/pubmed/9118887
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author Norpoth, K H
Müller, G
Schell, C
Jorg, E
author_facet Norpoth, K H
Müller, G
Schell, C
Jorg, E
author_sort Norpoth, K H
collection PubMed
description Comparative investigations with synthetic N7-phenylguanine were carried out to clarify whether this compound is eliminated via the urine of rats as a benzene-derived nucleic acid adduct. As sensitive methods for detecting trace amounts of the compound, gas chromatography-mass spectroscopy, high performance liquid chromatography, and two immunoassays (enzyme-linked immunosorbent assay and fluoroimmunoassay) with appropriate monoclonal antibodies were used. The results indicate the excretion of several benzene-related guanine adducts slightly different from N7-phenylguanine that may possibly be hydroxylated. These adducts differ also from (O6-, N2- and C8-phenylguanine, respectively.
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spelling pubmed-14697372006-06-01 Phenylguanine found in urine after benzene exposure. Norpoth, K H Müller, G Schell, C Jorg, E Environ Health Perspect Research Article Comparative investigations with synthetic N7-phenylguanine were carried out to clarify whether this compound is eliminated via the urine of rats as a benzene-derived nucleic acid adduct. As sensitive methods for detecting trace amounts of the compound, gas chromatography-mass spectroscopy, high performance liquid chromatography, and two immunoassays (enzyme-linked immunosorbent assay and fluoroimmunoassay) with appropriate monoclonal antibodies were used. The results indicate the excretion of several benzene-related guanine adducts slightly different from N7-phenylguanine that may possibly be hydroxylated. These adducts differ also from (O6-, N2- and C8-phenylguanine, respectively. 1996-12 /pmc/articles/PMC1469737/ /pubmed/9118887 Text en
spellingShingle Research Article
Norpoth, K H
Müller, G
Schell, C
Jorg, E
Phenylguanine found in urine after benzene exposure.
title Phenylguanine found in urine after benzene exposure.
title_full Phenylguanine found in urine after benzene exposure.
title_fullStr Phenylguanine found in urine after benzene exposure.
title_full_unstemmed Phenylguanine found in urine after benzene exposure.
title_short Phenylguanine found in urine after benzene exposure.
title_sort phenylguanine found in urine after benzene exposure.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469737/
https://www.ncbi.nlm.nih.gov/pubmed/9118887
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AT mullerg phenylguaninefoundinurineafterbenzeneexposure
AT schellc phenylguaninefoundinurineafterbenzeneexposure
AT jorge phenylguaninefoundinurineafterbenzeneexposure

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