Radiation-induced double-strand modification in calf thymus DNA in the presence of 1,2-dihydroxy-9,10-anthraquinone and its Cu(II) complex.

When cells or DNA is exposed to ionizing radiation, the radicals produced in the irradiated sample will modify the base-pair region of the double strands. Effects of 1,2-dihydroxy-9,10-anthraquinone (DHA) and its Cu(II) complex on the radiation-induced modification of double-strands in calf thymus D...

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Detalles Bibliográficos
Autores principales: Das, S, Saha, A, Mandal, P C
Formato: Texto
Lenguaje:English
Publicado: 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469930/
https://www.ncbi.nlm.nih.gov/pubmed/9467063
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author Das, S
Saha, A
Mandal, P C
author_facet Das, S
Saha, A
Mandal, P C
author_sort Das, S
collection PubMed
description When cells or DNA is exposed to ionizing radiation, the radicals produced in the irradiated sample will modify the base-pair region of the double strands. Effects of 1,2-dihydroxy-9,10-anthraquinone (DHA) and its Cu(II) complex on the radiation-induced modification of double-strands in calf thymus DNA were studied using ethidium bromide as a fluorescent probe. Our results show that the Cu(II)-DHA complex is more efficient in modifying the base-pair region in double-stranded DNA compared to free DHA.
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spelling pubmed-14699302006-06-01 Radiation-induced double-strand modification in calf thymus DNA in the presence of 1,2-dihydroxy-9,10-anthraquinone and its Cu(II) complex. Das, S Saha, A Mandal, P C Environ Health Perspect Research Article When cells or DNA is exposed to ionizing radiation, the radicals produced in the irradiated sample will modify the base-pair region of the double strands. Effects of 1,2-dihydroxy-9,10-anthraquinone (DHA) and its Cu(II) complex on the radiation-induced modification of double-strands in calf thymus DNA were studied using ethidium bromide as a fluorescent probe. Our results show that the Cu(II)-DHA complex is more efficient in modifying the base-pair region in double-stranded DNA compared to free DHA. 1997-12 /pmc/articles/PMC1469930/ /pubmed/9467063 Text en
spellingShingle Research Article
Das, S
Saha, A
Mandal, P C
Radiation-induced double-strand modification in calf thymus DNA in the presence of 1,2-dihydroxy-9,10-anthraquinone and its Cu(II) complex.
title Radiation-induced double-strand modification in calf thymus DNA in the presence of 1,2-dihydroxy-9,10-anthraquinone and its Cu(II) complex.
title_full Radiation-induced double-strand modification in calf thymus DNA in the presence of 1,2-dihydroxy-9,10-anthraquinone and its Cu(II) complex.
title_fullStr Radiation-induced double-strand modification in calf thymus DNA in the presence of 1,2-dihydroxy-9,10-anthraquinone and its Cu(II) complex.
title_full_unstemmed Radiation-induced double-strand modification in calf thymus DNA in the presence of 1,2-dihydroxy-9,10-anthraquinone and its Cu(II) complex.
title_short Radiation-induced double-strand modification in calf thymus DNA in the presence of 1,2-dihydroxy-9,10-anthraquinone and its Cu(II) complex.
title_sort radiation-induced double-strand modification in calf thymus dna in the presence of 1,2-dihydroxy-9,10-anthraquinone and its cu(ii) complex.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469930/
https://www.ncbi.nlm.nih.gov/pubmed/9467063
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