Genetic polymorphism of cytochrome P450 as a biomarker of susceptibility to environmental toxicity.

Cytochrome P450 (CYP) enzymes are responsible for the metabolism of numerous xenobiotics and endogenous compounds, including the metabolic activation of most environmental toxic chemicals and carcinogens. Both metabolic and genetic polymorphisms have been identified for human CYP enzymes. The associ...

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Detalles Bibliográficos
Autores principales: Hong, J Y, Yang, C S
Formato: Texto
Lenguaje:English
Publicado: 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470024/
https://www.ncbi.nlm.nih.gov/pubmed/9255558
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author Hong, J Y
Yang, C S
author_facet Hong, J Y
Yang, C S
author_sort Hong, J Y
collection PubMed
description Cytochrome P450 (CYP) enzymes are responsible for the metabolism of numerous xenobiotics and endogenous compounds, including the metabolic activation of most environmental toxic chemicals and carcinogens. Both metabolic and genetic polymorphisms have been identified for human CYP enzymes. The association of CYP genetic polymorphism and human cancer risk, and susceptibility to environmental hazards, have received increasing attention. This article briefly reviews the approaches and methods currently used in CYP genetic polymorphism studies. In addition, the current status and perspectives of using CYP genetic polymorphism as a biomarker of individual susceptibility to cancer and environmental toxicity are discussed.
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spelling pubmed-14700242006-06-01 Genetic polymorphism of cytochrome P450 as a biomarker of susceptibility to environmental toxicity. Hong, J Y Yang, C S Environ Health Perspect Research Article Cytochrome P450 (CYP) enzymes are responsible for the metabolism of numerous xenobiotics and endogenous compounds, including the metabolic activation of most environmental toxic chemicals and carcinogens. Both metabolic and genetic polymorphisms have been identified for human CYP enzymes. The association of CYP genetic polymorphism and human cancer risk, and susceptibility to environmental hazards, have received increasing attention. This article briefly reviews the approaches and methods currently used in CYP genetic polymorphism studies. In addition, the current status and perspectives of using CYP genetic polymorphism as a biomarker of individual susceptibility to cancer and environmental toxicity are discussed. 1997-06 /pmc/articles/PMC1470024/ /pubmed/9255558 Text en
spellingShingle Research Article
Hong, J Y
Yang, C S
Genetic polymorphism of cytochrome P450 as a biomarker of susceptibility to environmental toxicity.
title Genetic polymorphism of cytochrome P450 as a biomarker of susceptibility to environmental toxicity.
title_full Genetic polymorphism of cytochrome P450 as a biomarker of susceptibility to environmental toxicity.
title_fullStr Genetic polymorphism of cytochrome P450 as a biomarker of susceptibility to environmental toxicity.
title_full_unstemmed Genetic polymorphism of cytochrome P450 as a biomarker of susceptibility to environmental toxicity.
title_short Genetic polymorphism of cytochrome P450 as a biomarker of susceptibility to environmental toxicity.
title_sort genetic polymorphism of cytochrome p450 as a biomarker of susceptibility to environmental toxicity.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470024/
https://www.ncbi.nlm.nih.gov/pubmed/9255558
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AT yangcs geneticpolymorphismofcytochromep450asabiomarkerofsusceptibilitytoenvironmentaltoxicity

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