Susceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers.

Exposure of mesothelial cells to asbestos fibers in vitro has been shown to induce DNA damage mediated by oxidants. An early cellular response to DNA damage is increased expression of the p53 protein. This protein induces transcription of genes that activate cell cycle checkpoints or induce apoptosi...

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Detalles Bibliográficos
Autores principales: Marsella, J M, Liu, B L, Vaslet, C A, Kane, A B
Formato: Texto
Lenguaje:English
Publicado: 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470134/
https://www.ncbi.nlm.nih.gov/pubmed/9400702
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author Marsella, J M
Liu, B L
Vaslet, C A
Kane, A B
author_facet Marsella, J M
Liu, B L
Vaslet, C A
Kane, A B
author_sort Marsella, J M
collection PubMed
description Exposure of mesothelial cells to asbestos fibers in vitro has been shown to induce DNA damage mediated by oxidants. An early cellular response to DNA damage is increased expression of the p53 protein. This protein induces transcription of genes that activate cell cycle checkpoints or induce apoptosis. A murine mesothelial cell line that spontaneously acquired a point mutation in the p53 gene shows increased sensitivity to DNA damage induced by crocidolite asbestos fibers. It is hypothesized that p53-deficient mice will show increased sensitivity to the genotoxic effects of asbestos and accelerated development of malignant mesotheliomas.
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spelling pubmed-14701342006-06-01 Susceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers. Marsella, J M Liu, B L Vaslet, C A Kane, A B Environ Health Perspect Research Article Exposure of mesothelial cells to asbestos fibers in vitro has been shown to induce DNA damage mediated by oxidants. An early cellular response to DNA damage is increased expression of the p53 protein. This protein induces transcription of genes that activate cell cycle checkpoints or induce apoptosis. A murine mesothelial cell line that spontaneously acquired a point mutation in the p53 gene shows increased sensitivity to DNA damage induced by crocidolite asbestos fibers. It is hypothesized that p53-deficient mice will show increased sensitivity to the genotoxic effects of asbestos and accelerated development of malignant mesotheliomas. 1997-09 /pmc/articles/PMC1470134/ /pubmed/9400702 Text en
spellingShingle Research Article
Marsella, J M
Liu, B L
Vaslet, C A
Kane, A B
Susceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers.
title Susceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers.
title_full Susceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers.
title_fullStr Susceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers.
title_full_unstemmed Susceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers.
title_short Susceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers.
title_sort susceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470134/
https://www.ncbi.nlm.nih.gov/pubmed/9400702
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AT vasletca susceptibilityofp53deficientmicetoinductionofmesotheliomabycrocidoliteasbestosfibers
AT kaneab susceptibilityofp53deficientmicetoinductionofmesotheliomabycrocidoliteasbestosfibers

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