Oncogenes and tumor-suppressor genes in mesothelioma--a synopsis.

Invariably mesothelioma is diagnosed late in the development of the disease when treatment is no longer effective. Therefore, a key to reducing the mortality rate of this neoplasm is knowledge of the general sequence of genetic events between initiation of mesothelial cells and the emergence of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Lechner, J F, Tesfaigzi, J, Gerwin, B I
Formato: Texto
Lenguaje:English
Publicado: 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470150/
https://www.ncbi.nlm.nih.gov/pubmed/9400701
_version_ 1782127765959475200
author Lechner, J F
Tesfaigzi, J
Gerwin, B I
author_facet Lechner, J F
Tesfaigzi, J
Gerwin, B I
author_sort Lechner, J F
collection PubMed
description Invariably mesothelioma is diagnosed late in the development of the disease when treatment is no longer effective. Therefore, a key to reducing the mortality rate of this neoplasm is knowledge of the general sequence of genetic events between initiation of mesothelial cells and the emergence of the metastatic tumor cells. Unfortunately, relatively little is known about the early changes in the genesis of this disease. Of the known changes, the most frequent are in the tumor-suppressor genes p16INK4a and NF2 and possibly the SV40 virus large T-antigen oncogene. The molecular nature of the changes in these genes as well as other alterations are addressed in this overview.
format Text
id pubmed-1470150
institution National Center for Biotechnology Information
language English
publishDate 1997
record_format MEDLINE/PubMed
spelling pubmed-14701502006-06-01 Oncogenes and tumor-suppressor genes in mesothelioma--a synopsis. Lechner, J F Tesfaigzi, J Gerwin, B I Environ Health Perspect Research Article Invariably mesothelioma is diagnosed late in the development of the disease when treatment is no longer effective. Therefore, a key to reducing the mortality rate of this neoplasm is knowledge of the general sequence of genetic events between initiation of mesothelial cells and the emergence of the metastatic tumor cells. Unfortunately, relatively little is known about the early changes in the genesis of this disease. Of the known changes, the most frequent are in the tumor-suppressor genes p16INK4a and NF2 and possibly the SV40 virus large T-antigen oncogene. The molecular nature of the changes in these genes as well as other alterations are addressed in this overview. 1997-09 /pmc/articles/PMC1470150/ /pubmed/9400701 Text en
spellingShingle Research Article
Lechner, J F
Tesfaigzi, J
Gerwin, B I
Oncogenes and tumor-suppressor genes in mesothelioma--a synopsis.
title Oncogenes and tumor-suppressor genes in mesothelioma--a synopsis.
title_full Oncogenes and tumor-suppressor genes in mesothelioma--a synopsis.
title_fullStr Oncogenes and tumor-suppressor genes in mesothelioma--a synopsis.
title_full_unstemmed Oncogenes and tumor-suppressor genes in mesothelioma--a synopsis.
title_short Oncogenes and tumor-suppressor genes in mesothelioma--a synopsis.
title_sort oncogenes and tumor-suppressor genes in mesothelioma--a synopsis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470150/
https://www.ncbi.nlm.nih.gov/pubmed/9400701
work_keys_str_mv AT lechnerjf oncogenesandtumorsuppressorgenesinmesotheliomaasynopsis
AT tesfaigzij oncogenesandtumorsuppressorgenesinmesotheliomaasynopsis
AT gerwinbi oncogenesandtumorsuppressorgenesinmesotheliomaasynopsis

Ejemplares similares