Bovine spongiform encephalopathy: is it an autoimmune disease due to bacteria showing molecular mimicry with brain antigens?

Bovine spongiform encephalopathy (BSE) could be an autoimmune disease produced following exposure of cattle to feedstuffs containing bacteria showing molecular mimicry between bacterial components and bovine tissue. Analysis of molecular sequence databases (Genbank and SwissProt) shows that three ba...

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Detalles Bibliográficos
Autores principales: Ebringer, A, Thorpe, C, Pirt, J, Wilson, C, Cunningham, P, Ettelaie, C
Formato: Texto
Lenguaje:English
Publicado: 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470340/
https://www.ncbi.nlm.nih.gov/pubmed/9370514
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author Ebringer, A
Thorpe, C
Pirt, J
Wilson, C
Cunningham, P
Ettelaie, C
author_facet Ebringer, A
Thorpe, C
Pirt, J
Wilson, C
Cunningham, P
Ettelaie, C
author_sort Ebringer, A
collection PubMed
description Bovine spongiform encephalopathy (BSE) could be an autoimmune disease produced following exposure of cattle to feedstuffs containing bacteria showing molecular mimicry between bacterial components and bovine tissue. Analysis of molecular sequence databases (Genbank and SwissProt) shows that three bacteria (Acinetobacter calcoaceticus,Ruminococcus albus, and Agrobacter tumefaciens) share sequences with the encephalitogenic peptide of bovine myelin, while three molecules in Escherichia coli show molecular mimicry with host-encoded prion protein. Immune responses against these bacteria at both T and B cell levels may cause neurological tissue injury resembling BSE. The role of these bacteria in BSE, if any, merits further investigation.
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spelling pubmed-14703402006-06-01 Bovine spongiform encephalopathy: is it an autoimmune disease due to bacteria showing molecular mimicry with brain antigens? Ebringer, A Thorpe, C Pirt, J Wilson, C Cunningham, P Ettelaie, C Environ Health Perspect Research Article Bovine spongiform encephalopathy (BSE) could be an autoimmune disease produced following exposure of cattle to feedstuffs containing bacteria showing molecular mimicry between bacterial components and bovine tissue. Analysis of molecular sequence databases (Genbank and SwissProt) shows that three bacteria (Acinetobacter calcoaceticus,Ruminococcus albus, and Agrobacter tumefaciens) share sequences with the encephalitogenic peptide of bovine myelin, while three molecules in Escherichia coli show molecular mimicry with host-encoded prion protein. Immune responses against these bacteria at both T and B cell levels may cause neurological tissue injury resembling BSE. The role of these bacteria in BSE, if any, merits further investigation. 1997-11 /pmc/articles/PMC1470340/ /pubmed/9370514 Text en
spellingShingle Research Article
Ebringer, A
Thorpe, C
Pirt, J
Wilson, C
Cunningham, P
Ettelaie, C
Bovine spongiform encephalopathy: is it an autoimmune disease due to bacteria showing molecular mimicry with brain antigens?
title Bovine spongiform encephalopathy: is it an autoimmune disease due to bacteria showing molecular mimicry with brain antigens?
title_full Bovine spongiform encephalopathy: is it an autoimmune disease due to bacteria showing molecular mimicry with brain antigens?
title_fullStr Bovine spongiform encephalopathy: is it an autoimmune disease due to bacteria showing molecular mimicry with brain antigens?
title_full_unstemmed Bovine spongiform encephalopathy: is it an autoimmune disease due to bacteria showing molecular mimicry with brain antigens?
title_short Bovine spongiform encephalopathy: is it an autoimmune disease due to bacteria showing molecular mimicry with brain antigens?
title_sort bovine spongiform encephalopathy: is it an autoimmune disease due to bacteria showing molecular mimicry with brain antigens?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470340/
https://www.ncbi.nlm.nih.gov/pubmed/9370514
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