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Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch

C (2) domains are well characterized as Ca (2+)/phospholipid-binding modules, but little is known about how they mediate protein–protein interactions. In neurons, a Munc13–1 C (2)A-domain/RIM zinc-finger domain (ZF) heterodimer couples synaptic vesicle priming to presynaptic plasticity. We now show...

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Detalles Bibliográficos
Autores principales:	Lu, Jun, Machius, Mischa, Dulubova, Irina, Dai, Han, Südhof, Thomas C, Tomchick, Diana R, Rizo, Josep
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2006
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472246/ https://www.ncbi.nlm.nih.gov/pubmed/16732694 http://dx.doi.org/10.1371/journal.pbio.0040192

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