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Depletion of SMN by RNA interference in HeLa cells induces defects in Cajal body formation

Neuronal degeneration in spinal muscular atrophy (SMA) is caused by reduced expression of the survival of motor neuron (SMN) protein. The SMN protein is ubiquitously expressed and is present both in the cytoplasm and in the nucleus where it localizes in Cajal bodies. The SMN complex plays an essenti...

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Detalles Bibliográficos
Autores principales:	Girard, Cyrille, Neel, Henry, Bertrand, Edouard, Bordonné, Rémy
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2006
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474063/ https://www.ncbi.nlm.nih.gov/pubmed/16738131 http://dx.doi.org/10.1093/nar/gkl374

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