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Analysis of HIV-1 replication block due to substitutions at F61 residue of reverse transcriptase reveals additional defects involving the RNase H function

We reported previously that substitutions F61L, F61W, F61Y and F61A in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase affect strand displacement synthesis [T. S. Fisher, T. Darden and V. R. Prasad (2003) J. Mol. Biol., 325, 443–459]. We have now determined the effect of these muta...

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Detalles Bibliográficos
Autores principales:	Mandal, Dibyakanti, Dash, Chandravanu, Le Grice, Stuart F. J., Prasad, Vinayaka R.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2006
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474072/ https://www.ncbi.nlm.nih.gov/pubmed/16723431 http://dx.doi.org/10.1093/nar/gkl360

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