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Effect of chloroacetic acids on the kidneys.

The effects of dichloroacetate (DCA) and trichloroacetate (TCA) administered in drinking water were studied. At high concentrations of either compound, weight loss, or failure to gain weight, was observed. Food consumption was also decreased; both effects were attributed to decreased water consumpti...

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Detalles Bibliográficos
Autor principal: Davis, M E
Formato: Texto
Lenguaje:English
Publicado: 1986
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474340/
https://www.ncbi.nlm.nih.gov/pubmed/3816724
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author Davis, M E
author_facet Davis, M E
author_sort Davis, M E
collection PubMed
description The effects of dichloroacetate (DCA) and trichloroacetate (TCA) administered in drinking water were studied. At high concentrations of either compound, weight loss, or failure to gain weight, was observed. Food consumption was also decreased; both effects were attributed to decreased water consumption. Renal phosphate-dependent glutaminase activity was increased at the highest concentration, and urinary ammonia was also increased. These changes indicated renal adaptation to an acid load. DCA, in pharmacological doses, impairs glucoenogenesis from lactate in part by decreasing lactate availability. Similar tendencies were observed in the present studies; however, female rats showed a biphasic response. At lower DCA concentrations, tissue lactate and plasma glucose concentrations were increased, whereas at higher concentrations of DCA, the expected decreases were observed.
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spelling pubmed-14743402006-06-09 Effect of chloroacetic acids on the kidneys. Davis, M E Environ Health Perspect Research Article The effects of dichloroacetate (DCA) and trichloroacetate (TCA) administered in drinking water were studied. At high concentrations of either compound, weight loss, or failure to gain weight, was observed. Food consumption was also decreased; both effects were attributed to decreased water consumption. Renal phosphate-dependent glutaminase activity was increased at the highest concentration, and urinary ammonia was also increased. These changes indicated renal adaptation to an acid load. DCA, in pharmacological doses, impairs glucoenogenesis from lactate in part by decreasing lactate availability. Similar tendencies were observed in the present studies; however, female rats showed a biphasic response. At lower DCA concentrations, tissue lactate and plasma glucose concentrations were increased, whereas at higher concentrations of DCA, the expected decreases were observed. 1986-11 /pmc/articles/PMC1474340/ /pubmed/3816724 Text en
spellingShingle Research Article
Davis, M E
Effect of chloroacetic acids on the kidneys.
title Effect of chloroacetic acids on the kidneys.
title_full Effect of chloroacetic acids on the kidneys.
title_fullStr Effect of chloroacetic acids on the kidneys.
title_full_unstemmed Effect of chloroacetic acids on the kidneys.
title_short Effect of chloroacetic acids on the kidneys.
title_sort effect of chloroacetic acids on the kidneys.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474340/
https://www.ncbi.nlm.nih.gov/pubmed/3816724
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