Induction of histamine release in vitro from rat peritoneal mast cells by extracts of grain dust.

The ability of extracts of grain dust and wheat to induce histamine release from rat peritoneal cells was investigated. Some grain dusts, with a high endotoxin content, were found to produce cytotoxic histamine release. Extract of wheat dust, with a low endotoxin release, produced noncytotoxic hista...

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Detalles Bibliográficos
Autores principales: Warren, C P, Holford-Strevens, V
Formato: Texto
Lenguaje:English
Publicado: 1986
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474368/
https://www.ncbi.nlm.nih.gov/pubmed/2423321
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author Warren, C P
Holford-Strevens, V
author_facet Warren, C P
Holford-Strevens, V
author_sort Warren, C P
collection PubMed
description The ability of extracts of grain dust and wheat to induce histamine release from rat peritoneal cells was investigated. Some grain dusts, with a high endotoxin content, were found to produce cytotoxic histamine release. Extract of wheat dust, with a low endotoxin release, produced noncytotoxic histamine release from peritoneal cells but not from purified mast cells. This reaction was dependent on the presence of phosphatidyl serine. The agent did not appear to be a lectin because histamine release was not enhanced by passive sensitization of mast cells with IgE. The activity occurred only over a narrow range of concentrations of the extract of wheat. The cause was unclear.
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spelling pubmed-14743682006-06-09 Induction of histamine release in vitro from rat peritoneal mast cells by extracts of grain dust. Warren, C P Holford-Strevens, V Environ Health Perspect Research Article The ability of extracts of grain dust and wheat to induce histamine release from rat peritoneal cells was investigated. Some grain dusts, with a high endotoxin content, were found to produce cytotoxic histamine release. Extract of wheat dust, with a low endotoxin release, produced noncytotoxic histamine release from peritoneal cells but not from purified mast cells. This reaction was dependent on the presence of phosphatidyl serine. The agent did not appear to be a lectin because histamine release was not enhanced by passive sensitization of mast cells with IgE. The activity occurred only over a narrow range of concentrations of the extract of wheat. The cause was unclear. 1986-04 /pmc/articles/PMC1474368/ /pubmed/2423321 Text en
spellingShingle Research Article
Warren, C P
Holford-Strevens, V
Induction of histamine release in vitro from rat peritoneal mast cells by extracts of grain dust.
title Induction of histamine release in vitro from rat peritoneal mast cells by extracts of grain dust.
title_full Induction of histamine release in vitro from rat peritoneal mast cells by extracts of grain dust.
title_fullStr Induction of histamine release in vitro from rat peritoneal mast cells by extracts of grain dust.
title_full_unstemmed Induction of histamine release in vitro from rat peritoneal mast cells by extracts of grain dust.
title_short Induction of histamine release in vitro from rat peritoneal mast cells by extracts of grain dust.
title_sort induction of histamine release in vitro from rat peritoneal mast cells by extracts of grain dust.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474368/
https://www.ncbi.nlm.nih.gov/pubmed/2423321
work_keys_str_mv AT warrencp inductionofhistaminereleaseinvitrofromratperitonealmastcellsbyextractsofgraindust
AT holfordstrevensv inductionofhistaminereleaseinvitrofromratperitonealmastcellsbyextractsofgraindust

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