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Animal model of grain worker's lung.

We examined the light microscopic changes in the lungs of rabbits exposed to grain dust for variable periods of time, to determine whether an animal model of grain worker's lung could be developed. Experimental animals were exposed to grain dust at a concentration of 20 mg/m3 for 7 hr/day, 5 da...

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Detalles Bibliográficos
Autores principales: Stepner, N, Broder, I, Baumal, R
Formato: Texto
Lenguaje:English
Publicado: 1986
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474377/
https://www.ncbi.nlm.nih.gov/pubmed/3709485
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author Stepner, N
Broder, I
Baumal, R
author_facet Stepner, N
Broder, I
Baumal, R
author_sort Stepner, N
collection PubMed
description We examined the light microscopic changes in the lungs of rabbits exposed to grain dust for variable periods of time, to determine whether an animal model of grain worker's lung could be developed. Experimental animals were exposed to grain dust at a concentration of 20 mg/m3 for 7 hr/day, 5 days/week, for up to 6 months. The lungs of these rabbits demonstrated a granulomatous interstitial pneumonitis associated with exudation of mononuclear cells into the alveoli and conducting airways. These changes appeared within 5 days of the onset of exposure and reached a peak at 3 weeks but were sustained through the longest exposure interval. No abnormalities were observed in the lungs of control rabbits. These results show three points of consistency with those obtained in epidemiologic studies of grain elevator workers. First, the rapid appearance of the experimental changes suggests that the mechanism of tissue injury may not be immunologic. Second, the occurrence of the histopathologic alterations in the interstitium, alveoli, and airways corresponds with the combined restrictive and obstructive ventilatory defect described in the human epidemiologic studies. Third, the absence of lung fibrosis in rabbits exposed to dust for 6 months suggests that the pneumonitis is reversible. Thus this experimental model shows promise of helping to clarify the nature and mechanism of the adverse pulmonary effects of grain dust.
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spelling pubmed-14743772006-06-09 Animal model of grain worker's lung. Stepner, N Broder, I Baumal, R Environ Health Perspect Research Article We examined the light microscopic changes in the lungs of rabbits exposed to grain dust for variable periods of time, to determine whether an animal model of grain worker's lung could be developed. Experimental animals were exposed to grain dust at a concentration of 20 mg/m3 for 7 hr/day, 5 days/week, for up to 6 months. The lungs of these rabbits demonstrated a granulomatous interstitial pneumonitis associated with exudation of mononuclear cells into the alveoli and conducting airways. These changes appeared within 5 days of the onset of exposure and reached a peak at 3 weeks but were sustained through the longest exposure interval. No abnormalities were observed in the lungs of control rabbits. These results show three points of consistency with those obtained in epidemiologic studies of grain elevator workers. First, the rapid appearance of the experimental changes suggests that the mechanism of tissue injury may not be immunologic. Second, the occurrence of the histopathologic alterations in the interstitium, alveoli, and airways corresponds with the combined restrictive and obstructive ventilatory defect described in the human epidemiologic studies. Third, the absence of lung fibrosis in rabbits exposed to dust for 6 months suggests that the pneumonitis is reversible. Thus this experimental model shows promise of helping to clarify the nature and mechanism of the adverse pulmonary effects of grain dust. 1986-04 /pmc/articles/PMC1474377/ /pubmed/3709485 Text en
spellingShingle Research Article
Stepner, N
Broder, I
Baumal, R
Animal model of grain worker's lung.
title Animal model of grain worker's lung.
title_full Animal model of grain worker's lung.
title_fullStr Animal model of grain worker's lung.
title_full_unstemmed Animal model of grain worker's lung.
title_short Animal model of grain worker's lung.
title_sort animal model of grain worker's lung.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474377/
https://www.ncbi.nlm.nih.gov/pubmed/3709485
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