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The role of oncogenes in chemical carcinogenesis.

Proto-oncogenes are cellular genes that are expressed during normal growth and developmental processes. Altered versions of normal proto-oncogenes have been implicated in the development of human neoplasia. In this report, we show the detection of activated proto-oncogenes in various spontaneous and...

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Detalles Bibliográficos
Autores principales: Stowers, S J, Maronpot, R R, Reynolds, S H, Anderson, M W
Formato: Texto
Lenguaje:English
Publicado: 1987
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474454/
https://www.ncbi.nlm.nih.gov/pubmed/3319570
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author Stowers, S J
Maronpot, R R
Reynolds, S H
Anderson, M W
author_facet Stowers, S J
Maronpot, R R
Reynolds, S H
Anderson, M W
author_sort Stowers, S J
collection PubMed
description Proto-oncogenes are cellular genes that are expressed during normal growth and developmental processes. Altered versions of normal proto-oncogenes have been implicated in the development of human neoplasia. In this report, we show the detection of activated proto-oncogenes in various spontaneous and chemically induced rodent tumors. The majority of activated proto-oncogenes found in these tumors are members of the ras gene family and have been activated by a point mutation. Characterization of the activating mutation may be useful in determining whether this proto-oncogene was activated by direct interaction of the chemical with the DNA. Comparison of activating lesions in spontaneous versus chemically induced tumors should be helpful in determining whether the chemical acts via a genotoxic or a nongenotoxic mechanism. All of this information may be helpful in the assessment of potential carcinogenic hazards of human exposure to chemicals.
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spelling pubmed-14744542006-06-09 The role of oncogenes in chemical carcinogenesis. Stowers, S J Maronpot, R R Reynolds, S H Anderson, M W Environ Health Perspect Research Article Proto-oncogenes are cellular genes that are expressed during normal growth and developmental processes. Altered versions of normal proto-oncogenes have been implicated in the development of human neoplasia. In this report, we show the detection of activated proto-oncogenes in various spontaneous and chemically induced rodent tumors. The majority of activated proto-oncogenes found in these tumors are members of the ras gene family and have been activated by a point mutation. Characterization of the activating mutation may be useful in determining whether this proto-oncogene was activated by direct interaction of the chemical with the DNA. Comparison of activating lesions in spontaneous versus chemically induced tumors should be helpful in determining whether the chemical acts via a genotoxic or a nongenotoxic mechanism. All of this information may be helpful in the assessment of potential carcinogenic hazards of human exposure to chemicals. 1987-11 /pmc/articles/PMC1474454/ /pubmed/3319570 Text en
spellingShingle Research Article
Stowers, S J
Maronpot, R R
Reynolds, S H
Anderson, M W
The role of oncogenes in chemical carcinogenesis.
title The role of oncogenes in chemical carcinogenesis.
title_full The role of oncogenes in chemical carcinogenesis.
title_fullStr The role of oncogenes in chemical carcinogenesis.
title_full_unstemmed The role of oncogenes in chemical carcinogenesis.
title_short The role of oncogenes in chemical carcinogenesis.
title_sort role of oncogenes in chemical carcinogenesis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474454/
https://www.ncbi.nlm.nih.gov/pubmed/3319570
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