Prostatic carcinogenesis evoked by cellular interaction.

Inoculation of tumorigenic prostatic stroma and nontumorigenic prostatic epithelia into the subcutaneous space of syngeneic rats induced the development of carcinosarcoma. The induced tumors, which were composed of a mixture of adenocarcinoma and fibrosarcoma, were androgen responsive. This model of...

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Detalles Bibliográficos
Autores principales: Chung, L W, Chang, S M, Bell, C, Zhau, H, Ro, J Y, von Eschenbach, A C
Formato: Texto
Lenguaje:English
Publicado: 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474533/
https://www.ncbi.nlm.nih.gov/pubmed/3383820
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author Chung, L W
Chang, S M
Bell, C
Zhau, H
Ro, J Y
von Eschenbach, A C
author_facet Chung, L W
Chang, S M
Bell, C
Zhau, H
Ro, J Y
von Eschenbach, A C
author_sort Chung, L W
collection PubMed
description Inoculation of tumorigenic prostatic stroma and nontumorigenic prostatic epithelia into the subcutaneous space of syngeneic rats induced the development of carcinosarcoma. The induced tumors, which were composed of a mixture of adenocarcinoma and fibrosarcoma, were androgen responsive. This model offers a novel mechanism for prostatic carcinogenesis in which prostatic fibroblasts determine epithelial growth, androgen responsiveness, and tumorigenicity. Our results emphasize the potential importance of an epigenetic pathway in prostatic carcinogenesis.
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spelling pubmed-14745332006-06-09 Prostatic carcinogenesis evoked by cellular interaction. Chung, L W Chang, S M Bell, C Zhau, H Ro, J Y von Eschenbach, A C Environ Health Perspect Research Article Inoculation of tumorigenic prostatic stroma and nontumorigenic prostatic epithelia into the subcutaneous space of syngeneic rats induced the development of carcinosarcoma. The induced tumors, which were composed of a mixture of adenocarcinoma and fibrosarcoma, were androgen responsive. This model offers a novel mechanism for prostatic carcinogenesis in which prostatic fibroblasts determine epithelial growth, androgen responsiveness, and tumorigenicity. Our results emphasize the potential importance of an epigenetic pathway in prostatic carcinogenesis. 1988-04 /pmc/articles/PMC1474533/ /pubmed/3383820 Text en
spellingShingle Research Article
Chung, L W
Chang, S M
Bell, C
Zhau, H
Ro, J Y
von Eschenbach, A C
Prostatic carcinogenesis evoked by cellular interaction.
title Prostatic carcinogenesis evoked by cellular interaction.
title_full Prostatic carcinogenesis evoked by cellular interaction.
title_fullStr Prostatic carcinogenesis evoked by cellular interaction.
title_full_unstemmed Prostatic carcinogenesis evoked by cellular interaction.
title_short Prostatic carcinogenesis evoked by cellular interaction.
title_sort prostatic carcinogenesis evoked by cellular interaction.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474533/
https://www.ncbi.nlm.nih.gov/pubmed/3383820
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AT bellc prostaticcarcinogenesisevokedbycellularinteraction
AT zhauh prostaticcarcinogenesisevokedbycellularinteraction
AT rojy prostaticcarcinogenesisevokedbycellularinteraction
AT voneschenbachac prostaticcarcinogenesisevokedbycellularinteraction

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