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Mesovarian leiomyomas in the rat.
Prolonged treatment with two chemically distinct beta-stimulants, Salbutamol and Terbutaline, resulted in mesovarian leiomyomas in Sprague-Dawley rats. Development of these tumors induced by Salbutamol was prevented by concurrent administration of the beta-blocker Propranolol. Mesovarian leiomyomas...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
1987
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474549/ https://www.ncbi.nlm.nih.gov/pubmed/3665855 |
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author | Gopinath, C Gibson, W A |
author_facet | Gopinath, C Gibson, W A |
author_sort | Gopinath, C |
collection | PubMed |
description | Prolonged treatment with two chemically distinct beta-stimulants, Salbutamol and Terbutaline, resulted in mesovarian leiomyomas in Sprague-Dawley rats. Development of these tumors induced by Salbutamol was prevented by concurrent administration of the beta-blocker Propranolol. Mesovarian leiomyomas induced by Salbutomol did not show any regression or progression during a 44-week postdosing recovery period. This report also gives the first recorded incidence of spontaneous mesovarian leiomyomas in the rat. |
format | Text |
id | pubmed-1474549 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1987 |
record_format | MEDLINE/PubMed |
spelling | pubmed-14745492006-06-09 Mesovarian leiomyomas in the rat. Gopinath, C Gibson, W A Environ Health Perspect Research Article Prolonged treatment with two chemically distinct beta-stimulants, Salbutamol and Terbutaline, resulted in mesovarian leiomyomas in Sprague-Dawley rats. Development of these tumors induced by Salbutamol was prevented by concurrent administration of the beta-blocker Propranolol. Mesovarian leiomyomas induced by Salbutomol did not show any regression or progression during a 44-week postdosing recovery period. This report also gives the first recorded incidence of spontaneous mesovarian leiomyomas in the rat. 1987-08 /pmc/articles/PMC1474549/ /pubmed/3665855 Text en |
spellingShingle | Research Article Gopinath, C Gibson, W A Mesovarian leiomyomas in the rat. |
title | Mesovarian leiomyomas in the rat. |
title_full | Mesovarian leiomyomas in the rat. |
title_fullStr | Mesovarian leiomyomas in the rat. |
title_full_unstemmed | Mesovarian leiomyomas in the rat. |
title_short | Mesovarian leiomyomas in the rat. |
title_sort | mesovarian leiomyomas in the rat. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474549/ https://www.ncbi.nlm.nih.gov/pubmed/3665855 |
work_keys_str_mv | AT gopinathc mesovarianleiomyomasintherat AT gibsonwa mesovarianleiomyomasintherat |