Induction of SOS functions in Escherichia coli and biosynthesis of nitrosamine in rabbits by nitrogen dioxide.

Nitrogen dioxide induced SOS functions in Salmonella typhimurium and Escherichia coli K-12 and was mutagenic in Escherichia coli WP2. When a rabbit was administered aminopyrine intravenously and administered nitrogen dioxide by inhalation, N-nitrosodimethylamine was detected in its blood. Analysis w...

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Autores principales: Kosaka, H, Uozumi, M, Nakajima, T
Formato: Texto
Lenguaje:English
Publicado: 1987
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474569/
https://www.ncbi.nlm.nih.gov/pubmed/3311723
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author Kosaka, H
Uozumi, M
Nakajima, T
author_facet Kosaka, H
Uozumi, M
Nakajima, T
author_sort Kosaka, H
collection PubMed
description Nitrogen dioxide induced SOS functions in Salmonella typhimurium and Escherichia coli K-12 and was mutagenic in Escherichia coli WP2. When a rabbit was administered aminopyrine intravenously and administered nitrogen dioxide by inhalation, N-nitrosodimethylamine was detected in its blood. Analysis was conducted with 15N-nitrosodimethylamine as an internal standard by a combination of capillary gas chromatography and mass spectrometry. Accompanying administration of cystamine increased the blood concentration of N-nitrosodimethylamine in the rabbit, suggesting inhibition of its metabolism. Concurrent sulfur trioxide inhalation increased N-nitrosodimethylamine formation in the rabbit.
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spelling pubmed-14745692006-06-09 Induction of SOS functions in Escherichia coli and biosynthesis of nitrosamine in rabbits by nitrogen dioxide. Kosaka, H Uozumi, M Nakajima, T Environ Health Perspect Research Article Nitrogen dioxide induced SOS functions in Salmonella typhimurium and Escherichia coli K-12 and was mutagenic in Escherichia coli WP2. When a rabbit was administered aminopyrine intravenously and administered nitrogen dioxide by inhalation, N-nitrosodimethylamine was detected in its blood. Analysis was conducted with 15N-nitrosodimethylamine as an internal standard by a combination of capillary gas chromatography and mass spectrometry. Accompanying administration of cystamine increased the blood concentration of N-nitrosodimethylamine in the rabbit, suggesting inhibition of its metabolism. Concurrent sulfur trioxide inhalation increased N-nitrosodimethylamine formation in the rabbit. 1987-08 /pmc/articles/PMC1474569/ /pubmed/3311723 Text en
spellingShingle Research Article
Kosaka, H
Uozumi, M
Nakajima, T
Induction of SOS functions in Escherichia coli and biosynthesis of nitrosamine in rabbits by nitrogen dioxide.
title Induction of SOS functions in Escherichia coli and biosynthesis of nitrosamine in rabbits by nitrogen dioxide.
title_full Induction of SOS functions in Escherichia coli and biosynthesis of nitrosamine in rabbits by nitrogen dioxide.
title_fullStr Induction of SOS functions in Escherichia coli and biosynthesis of nitrosamine in rabbits by nitrogen dioxide.
title_full_unstemmed Induction of SOS functions in Escherichia coli and biosynthesis of nitrosamine in rabbits by nitrogen dioxide.
title_short Induction of SOS functions in Escherichia coli and biosynthesis of nitrosamine in rabbits by nitrogen dioxide.
title_sort induction of sos functions in escherichia coli and biosynthesis of nitrosamine in rabbits by nitrogen dioxide.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474569/
https://www.ncbi.nlm.nih.gov/pubmed/3311723
work_keys_str_mv AT kosakah inductionofsosfunctionsinescherichiacoliandbiosynthesisofnitrosamineinrabbitsbynitrogendioxide
AT uozumim inductionofsosfunctionsinescherichiacoliandbiosynthesisofnitrosamineinrabbitsbynitrogendioxide
AT nakajimat inductionofsosfunctionsinescherichiacoliandbiosynthesisofnitrosamineinrabbitsbynitrogendioxide

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