Cargando…

Increase in the blood pressure of rats chronically fed low levels of lead.

Groups of 15 to 18 female weanling Long-Evans rats fed a rye-based diet low in lead (0.25 ppm) were exposed to 0.1, 1.0, and 5.0 ppm lead in drinking water. No suggestion of clinical lead toxicity was recognized. Systolic pressures were measured at 3-month intervals after weaning. The groups of lead...

Descripción completa

Detalles Bibliográficos
Autores principales: Perry, H M, Erlanger, M W, Perry, E F
Formato: Texto
Lenguaje:English
Publicado: 1988
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474601/
https://www.ncbi.nlm.nih.gov/pubmed/3203629
_version_ 1782127945092956160
author Perry, H M
Erlanger, M W
Perry, E F
author_facet Perry, H M
Erlanger, M W
Perry, E F
author_sort Perry, H M
collection PubMed
description Groups of 15 to 18 female weanling Long-Evans rats fed a rye-based diet low in lead (0.25 ppm) were exposed to 0.1, 1.0, and 5.0 ppm lead in drinking water. No suggestion of clinical lead toxicity was recognized. Systolic pressures were measured at 3-month intervals after weaning. The groups of lead-exposed animals had consistently and significantly higher average pressures than control animals, the increase approximating 15 mm Hg. With the lowest lead exposure (0.1 ppm), the increase in average pressure was gradual, being half minimal at 3 months and requiring 1 year to become maximal. After 1 year, half of these rats had pressures from 0 to 10 mm Hg above the control average; 40, 20, and 10% had pressures that were 20, 30, and 40 mm Hg, respectively, above the control average. Thus, rats exposed to lead in amounts comparable to the environmental exposure of many Americans had an average elevation in systolic pressure comparable to that of human beings with essential hypertension.
format Text
id pubmed-1474601
institution National Center for Biotechnology Information
language English
publishDate 1988
record_format MEDLINE/PubMed
spelling pubmed-14746012006-06-09 Increase in the blood pressure of rats chronically fed low levels of lead. Perry, H M Erlanger, M W Perry, E F Environ Health Perspect Research Article Groups of 15 to 18 female weanling Long-Evans rats fed a rye-based diet low in lead (0.25 ppm) were exposed to 0.1, 1.0, and 5.0 ppm lead in drinking water. No suggestion of clinical lead toxicity was recognized. Systolic pressures were measured at 3-month intervals after weaning. The groups of lead-exposed animals had consistently and significantly higher average pressures than control animals, the increase approximating 15 mm Hg. With the lowest lead exposure (0.1 ppm), the increase in average pressure was gradual, being half minimal at 3 months and requiring 1 year to become maximal. After 1 year, half of these rats had pressures from 0 to 10 mm Hg above the control average; 40, 20, and 10% had pressures that were 20, 30, and 40 mm Hg, respectively, above the control average. Thus, rats exposed to lead in amounts comparable to the environmental exposure of many Americans had an average elevation in systolic pressure comparable to that of human beings with essential hypertension. 1988-06 /pmc/articles/PMC1474601/ /pubmed/3203629 Text en
spellingShingle Research Article
Perry, H M
Erlanger, M W
Perry, E F
Increase in the blood pressure of rats chronically fed low levels of lead.
title Increase in the blood pressure of rats chronically fed low levels of lead.
title_full Increase in the blood pressure of rats chronically fed low levels of lead.
title_fullStr Increase in the blood pressure of rats chronically fed low levels of lead.
title_full_unstemmed Increase in the blood pressure of rats chronically fed low levels of lead.
title_short Increase in the blood pressure of rats chronically fed low levels of lead.
title_sort increase in the blood pressure of rats chronically fed low levels of lead.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474601/
https://www.ncbi.nlm.nih.gov/pubmed/3203629
work_keys_str_mv AT perryhm increaseinthebloodpressureofratschronicallyfedlowlevelsoflead
AT erlangermw increaseinthebloodpressureofratschronicallyfedlowlevelsoflead
AT perryef increaseinthebloodpressureofratschronicallyfedlowlevelsoflead