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Epidemiological and experimental studies on the effects of methyl isocyanate on the course of pregnancy.

Although press reports indicate that the leakage of methyl isocyanate (MIC) on December 3, 1984, in Bhopal has led to an increase in spontaneous abortions, stillbirths, infant mortality, and fetal abnormalities, no clinical or experimental studies on the reproductive toxicity of MIC were reported in...

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Autor principal: Varma, D R
Formato: Texto
Lenguaje:English
Publicado: 1987
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474644/
https://www.ncbi.nlm.nih.gov/pubmed/3622430
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author Varma, D R
author_facet Varma, D R
author_sort Varma, D R
collection PubMed
description Although press reports indicate that the leakage of methyl isocyanate (MIC) on December 3, 1984, in Bhopal has led to an increase in spontaneous abortions, stillbirths, infant mortality, and fetal abnormalities, no clinical or experimental studies on the reproductive toxicity of MIC were reported in scientific journals for several months after the accident. We therefore conducted, 9 months after the accident, a preliminary survey of 3270 families in Bhopal and experimental studies on the effects of MIC in pregnant mice. It was found that 43% of pregnancies in women residing near the Union Carbide pesticide plant did not result in the birth of a live child. Likewise, exposure of mice to relatively low concentrations of MIC (9 and 15 ppm) for 3 hr caused complete resorption in more than 75% of animals. A decrease in fetal and placental weights was observed at 2 to 15 ppm MIC. In general, the experimental findings in mice corroborate the epidemiological data from Bhopal. The mechanism of the fetal toxicity of MIC remains to be established.
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spelling pubmed-14746442006-06-09 Epidemiological and experimental studies on the effects of methyl isocyanate on the course of pregnancy. Varma, D R Environ Health Perspect Research Article Although press reports indicate that the leakage of methyl isocyanate (MIC) on December 3, 1984, in Bhopal has led to an increase in spontaneous abortions, stillbirths, infant mortality, and fetal abnormalities, no clinical or experimental studies on the reproductive toxicity of MIC were reported in scientific journals for several months after the accident. We therefore conducted, 9 months after the accident, a preliminary survey of 3270 families in Bhopal and experimental studies on the effects of MIC in pregnant mice. It was found that 43% of pregnancies in women residing near the Union Carbide pesticide plant did not result in the birth of a live child. Likewise, exposure of mice to relatively low concentrations of MIC (9 and 15 ppm) for 3 hr caused complete resorption in more than 75% of animals. A decrease in fetal and placental weights was observed at 2 to 15 ppm MIC. In general, the experimental findings in mice corroborate the epidemiological data from Bhopal. The mechanism of the fetal toxicity of MIC remains to be established. 1987-06 /pmc/articles/PMC1474644/ /pubmed/3622430 Text en
spellingShingle Research Article
Varma, D R
Epidemiological and experimental studies on the effects of methyl isocyanate on the course of pregnancy.
title Epidemiological and experimental studies on the effects of methyl isocyanate on the course of pregnancy.
title_full Epidemiological and experimental studies on the effects of methyl isocyanate on the course of pregnancy.
title_fullStr Epidemiological and experimental studies on the effects of methyl isocyanate on the course of pregnancy.
title_full_unstemmed Epidemiological and experimental studies on the effects of methyl isocyanate on the course of pregnancy.
title_short Epidemiological and experimental studies on the effects of methyl isocyanate on the course of pregnancy.
title_sort epidemiological and experimental studies on the effects of methyl isocyanate on the course of pregnancy.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474644/
https://www.ncbi.nlm.nih.gov/pubmed/3622430
work_keys_str_mv AT varmadr epidemiologicalandexperimentalstudiesontheeffectsofmethylisocyanateonthecourseofpregnancy