Cargando…

Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug.

Peroxisome proliferation is inducible in hepatocytes of rodent and nonrodent species by structurally dissimilar hypolipidemic drugs and certain phthalate ester plasticizers. The induction of peroxisome proliferation appears to be a tissue specific response limited largely to the hepatocyte. Peroxiso...

Descripción completa

Detalles Bibliográficos
Autores principales: Reddy, J K, Reddy, M K, Usman, M I, Lalwani, N D, Rao, M S
Formato: Texto
Lenguaje:English
Publicado: 1986
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474684/
https://www.ncbi.nlm.nih.gov/pubmed/3709457
_version_ 1782127963490222080
author Reddy, J K
Reddy, M K
Usman, M I
Lalwani, N D
Rao, M S
author_facet Reddy, J K
Reddy, M K
Usman, M I
Lalwani, N D
Rao, M S
author_sort Reddy, J K
collection PubMed
description Peroxisome proliferation is inducible in hepatocytes of rodent and nonrodent species by structurally dissimilar hypolipidemic drugs and certain phthalate ester plasticizers. The induction of peroxisome proliferation appears to be a tissue specific response limited largely to the hepatocyte. Peroxisome proliferation is associated with increases in the activity of the H2O2-generating peroxisomal fatty acid beta-oxidation system and in the amount of peroxisome proliferation-associated 80,000 MW polypeptide (PPA-80). Chronic administration of these non-DNA damaging and nonmutagenic peroxisome proliferators to rats and mice results in the development of hepatocellular carcinomas. Comparative morphometric and biochemical data from rats treated with varying dose levels of ciprofibrate, a hypolipidemic drug, and di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate, the widely used plasticizers, indicate that the hepatocarcinogenic potency of these agents is correlatable with their ability to induce peroxisome proliferation, peroxisomal beta-oxidation and PPA-80. Available evidence strongly favors the role of peroxisome proliferation-associated oxidative stress in the induction of liver tumors by peroxisome proliferators.
format Text
id pubmed-1474684
institution National Center for Biotechnology Information
language English
publishDate 1986
record_format MEDLINE/PubMed
spelling pubmed-14746842006-06-09 Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug. Reddy, J K Reddy, M K Usman, M I Lalwani, N D Rao, M S Environ Health Perspect Research Article Peroxisome proliferation is inducible in hepatocytes of rodent and nonrodent species by structurally dissimilar hypolipidemic drugs and certain phthalate ester plasticizers. The induction of peroxisome proliferation appears to be a tissue specific response limited largely to the hepatocyte. Peroxisome proliferation is associated with increases in the activity of the H2O2-generating peroxisomal fatty acid beta-oxidation system and in the amount of peroxisome proliferation-associated 80,000 MW polypeptide (PPA-80). Chronic administration of these non-DNA damaging and nonmutagenic peroxisome proliferators to rats and mice results in the development of hepatocellular carcinomas. Comparative morphometric and biochemical data from rats treated with varying dose levels of ciprofibrate, a hypolipidemic drug, and di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate, the widely used plasticizers, indicate that the hepatocarcinogenic potency of these agents is correlatable with their ability to induce peroxisome proliferation, peroxisomal beta-oxidation and PPA-80. Available evidence strongly favors the role of peroxisome proliferation-associated oxidative stress in the induction of liver tumors by peroxisome proliferators. 1986-03 /pmc/articles/PMC1474684/ /pubmed/3709457 Text en
spellingShingle Research Article
Reddy, J K
Reddy, M K
Usman, M I
Lalwani, N D
Rao, M S
Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug.
title Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug.
title_full Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug.
title_fullStr Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug.
title_full_unstemmed Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug.
title_short Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug.
title_sort comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474684/
https://www.ncbi.nlm.nih.gov/pubmed/3709457
work_keys_str_mv AT reddyjk comparisonofhepaticperoxisomeproliferativeeffectanditsimplicationforhepatocarcinogenicityofphthalateestersdi2ethylhexylphthalateanddi2ethylhexyladipatewithahypolipidemicdrug
AT reddymk comparisonofhepaticperoxisomeproliferativeeffectanditsimplicationforhepatocarcinogenicityofphthalateestersdi2ethylhexylphthalateanddi2ethylhexyladipatewithahypolipidemicdrug
AT usmanmi comparisonofhepaticperoxisomeproliferativeeffectanditsimplicationforhepatocarcinogenicityofphthalateestersdi2ethylhexylphthalateanddi2ethylhexyladipatewithahypolipidemicdrug
AT lalwanind comparisonofhepaticperoxisomeproliferativeeffectanditsimplicationforhepatocarcinogenicityofphthalateestersdi2ethylhexylphthalateanddi2ethylhexyladipatewithahypolipidemicdrug
AT raoms comparisonofhepaticperoxisomeproliferativeeffectanditsimplicationforhepatocarcinogenicityofphthalateestersdi2ethylhexylphthalateanddi2ethylhexyladipatewithahypolipidemicdrug