Effects of toxaphene on hepatic enzyme induction and circulating steroid levels in the rat.

Rats were given a single dose of toxaphene (120 mg/kg, equivalent to 1/2 LD50) and sacrificed at 1, 5, and 15 days. Liver weight and hepatic microsomal enzyme activity were increased at day 5 and 15. The level of plasma testosterone was significantly decreased at day 15. In a second experiment rats...

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Detalles Bibliográficos
Autor principal: Peakall, D B
Formato: Texto
Lenguaje:English
Publicado: 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475012/
https://www.ncbi.nlm.nih.gov/pubmed/1269498
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author Peakall, D B
author_facet Peakall, D B
author_sort Peakall, D B
collection PubMed
description Rats were given a single dose of toxaphene (120 mg/kg, equivalent to 1/2 LD50) and sacrificed at 1, 5, and 15 days. Liver weight and hepatic microsomal enzyme activity were increased at day 5 and 15. The level of plasma testosterone was significantly decreased at day 15. In a second experiment rats were given 2.4 mg/kg daily and sacrificed at 1, 3 and 6 months. Liver weight and microsomal enzyme activity were significantly increased over controls; enzyme activity was, however, decreasing by the end of the experiment. Plasma testosterone levels were not affected. It is concluded that enhanced hepatic enzyme induction causes only a transient drop in circulating testosterone levels followed by a return to normal values.
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spelling pubmed-14750122006-06-09 Effects of toxaphene on hepatic enzyme induction and circulating steroid levels in the rat. Peakall, D B Environ Health Perspect Research Article Rats were given a single dose of toxaphene (120 mg/kg, equivalent to 1/2 LD50) and sacrificed at 1, 5, and 15 days. Liver weight and hepatic microsomal enzyme activity were increased at day 5 and 15. The level of plasma testosterone was significantly decreased at day 15. In a second experiment rats were given 2.4 mg/kg daily and sacrificed at 1, 3 and 6 months. Liver weight and microsomal enzyme activity were significantly increased over controls; enzyme activity was, however, decreasing by the end of the experiment. Plasma testosterone levels were not affected. It is concluded that enhanced hepatic enzyme induction causes only a transient drop in circulating testosterone levels followed by a return to normal values. 1976-02 /pmc/articles/PMC1475012/ /pubmed/1269498 Text en
spellingShingle Research Article
Peakall, D B
Effects of toxaphene on hepatic enzyme induction and circulating steroid levels in the rat.
title Effects of toxaphene on hepatic enzyme induction and circulating steroid levels in the rat.
title_full Effects of toxaphene on hepatic enzyme induction and circulating steroid levels in the rat.
title_fullStr Effects of toxaphene on hepatic enzyme induction and circulating steroid levels in the rat.
title_full_unstemmed Effects of toxaphene on hepatic enzyme induction and circulating steroid levels in the rat.
title_short Effects of toxaphene on hepatic enzyme induction and circulating steroid levels in the rat.
title_sort effects of toxaphene on hepatic enzyme induction and circulating steroid levels in the rat.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475012/
https://www.ncbi.nlm.nih.gov/pubmed/1269498
work_keys_str_mv AT peakalldb effectsoftoxapheneonhepaticenzymeinductionandcirculatingsteroidlevelsintherat

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