Effect of platinum and palladium salts on thymidine incorporation into DNA of rat tissues.

The intraperitoneal administration of PtCl4 or Pd(NO3)2 at levels of 28 or 56 mumole/kg body weight decreased the thymidine incorporation into DNA of spleen, liver, kidney, and testis. Spleen was most sensitive to both the platinum and the palladium salt. In liver, DNA syntheses in parenchymal cells...

Descripción completa

Detalles Bibliográficos
Autores principales: Fisher, R F, Holbrook, D J, Leake, H B, Brubaker, P E
Formato: Texto
Lenguaje:English
Publicado: 1975
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475016/
https://www.ncbi.nlm.nih.gov/pubmed/1227861
_version_ 1782128010234691584
author Fisher, R F
Holbrook, D J
Leake, H B
Brubaker, P E
author_facet Fisher, R F
Holbrook, D J
Leake, H B
Brubaker, P E
author_sort Fisher, R F
collection PubMed
description The intraperitoneal administration of PtCl4 or Pd(NO3)2 at levels of 28 or 56 mumole/kg body weight decreased the thymidine incorporation into DNA of spleen, liver, kidney, and testis. Spleen was most sensitive to both the platinum and the palladium salt. In liver, DNA syntheses in parenchymal cells and stromal cells were about equally sensitive to PtCl4. In control rats, only 20-30% of the 3H in the acid-soluble fraction of liver or spleen was in the form of thymidine and its phosphate esters 2 hr after the intraperitoneal injection of 3H-thymidine; prior injection of PtCl4 (56 mumol/kg body weight) did not change the pattern.
format Text
id pubmed-1475016
institution National Center for Biotechnology Information
language English
publishDate 1975
record_format MEDLINE/PubMed
spelling pubmed-14750162006-06-09 Effect of platinum and palladium salts on thymidine incorporation into DNA of rat tissues. Fisher, R F Holbrook, D J Leake, H B Brubaker, P E Environ Health Perspect Research Article The intraperitoneal administration of PtCl4 or Pd(NO3)2 at levels of 28 or 56 mumole/kg body weight decreased the thymidine incorporation into DNA of spleen, liver, kidney, and testis. Spleen was most sensitive to both the platinum and the palladium salt. In liver, DNA syntheses in parenchymal cells and stromal cells were about equally sensitive to PtCl4. In control rats, only 20-30% of the 3H in the acid-soluble fraction of liver or spleen was in the form of thymidine and its phosphate esters 2 hr after the intraperitoneal injection of 3H-thymidine; prior injection of PtCl4 (56 mumol/kg body weight) did not change the pattern. 1975-12 /pmc/articles/PMC1475016/ /pubmed/1227861 Text en
spellingShingle Research Article
Fisher, R F
Holbrook, D J
Leake, H B
Brubaker, P E
Effect of platinum and palladium salts on thymidine incorporation into DNA of rat tissues.
title Effect of platinum and palladium salts on thymidine incorporation into DNA of rat tissues.
title_full Effect of platinum and palladium salts on thymidine incorporation into DNA of rat tissues.
title_fullStr Effect of platinum and palladium salts on thymidine incorporation into DNA of rat tissues.
title_full_unstemmed Effect of platinum and palladium salts on thymidine incorporation into DNA of rat tissues.
title_short Effect of platinum and palladium salts on thymidine incorporation into DNA of rat tissues.
title_sort effect of platinum and palladium salts on thymidine incorporation into dna of rat tissues.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475016/
https://www.ncbi.nlm.nih.gov/pubmed/1227861
work_keys_str_mv AT fisherrf effectofplatinumandpalladiumsaltsonthymidineincorporationintodnaofrattissues
AT holbrookdj effectofplatinumandpalladiumsaltsonthymidineincorporationintodnaofrattissues
AT leakehb effectofplatinumandpalladiumsaltsonthymidineincorporationintodnaofrattissues
AT brubakerpe effectofplatinumandpalladiumsaltsonthymidineincorporationintodnaofrattissues

Ejemplares similares