Effect of nickel chloride on primary antibody production in the spleen.

Mice immunized intraperitoneally with sheep erythrocytes were treated with nickel chloride, a common particulate air pollutant. Primary antibody production in the spleen was examined using a hemolytic plaque technique. A negative linear dose-response relationship (p is less than 0.05) was observed b...

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Detalles Bibliográficos
Autores principales: Graham, J A, Gardner, D E, Miller, F J, Daniels, M J, Coffin, D L
Formato: Texto
Lenguaje:English
Publicado: 1975
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475024/
https://www.ncbi.nlm.nih.gov/pubmed/776602
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author Graham, J A
Gardner, D E
Miller, F J
Daniels, M J
Coffin, D L
author_facet Graham, J A
Gardner, D E
Miller, F J
Daniels, M J
Coffin, D L
author_sort Graham, J A
collection PubMed
description Mice immunized intraperitoneally with sheep erythrocytes were treated with nickel chloride, a common particulate air pollutant. Primary antibody production in the spleen was examined using a hemolytic plaque technique. A negative linear dose-response relationship (p is less than 0.05) was observed between the logarithm of (plaques/10(6) cells) and the nickel concentration administered. Mice injected with 3.09 mug Ni2+/g body weight displayed lymphocyte function similar to that of control mice. However, injection of 9.26-12.34 mug Ni2+/g caused significant immunosupression (p is less than 0.05).
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spelling pubmed-14750242006-06-09 Effect of nickel chloride on primary antibody production in the spleen. Graham, J A Gardner, D E Miller, F J Daniels, M J Coffin, D L Environ Health Perspect Research Article Mice immunized intraperitoneally with sheep erythrocytes were treated with nickel chloride, a common particulate air pollutant. Primary antibody production in the spleen was examined using a hemolytic plaque technique. A negative linear dose-response relationship (p is less than 0.05) was observed between the logarithm of (plaques/10(6) cells) and the nickel concentration administered. Mice injected with 3.09 mug Ni2+/g body weight displayed lymphocyte function similar to that of control mice. However, injection of 9.26-12.34 mug Ni2+/g caused significant immunosupression (p is less than 0.05). 1975-12 /pmc/articles/PMC1475024/ /pubmed/776602 Text en
spellingShingle Research Article
Graham, J A
Gardner, D E
Miller, F J
Daniels, M J
Coffin, D L
Effect of nickel chloride on primary antibody production in the spleen.
title Effect of nickel chloride on primary antibody production in the spleen.
title_full Effect of nickel chloride on primary antibody production in the spleen.
title_fullStr Effect of nickel chloride on primary antibody production in the spleen.
title_full_unstemmed Effect of nickel chloride on primary antibody production in the spleen.
title_short Effect of nickel chloride on primary antibody production in the spleen.
title_sort effect of nickel chloride on primary antibody production in the spleen.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475024/
https://www.ncbi.nlm.nih.gov/pubmed/776602
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AT millerfj effectofnickelchlorideonprimaryantibodyproductioninthespleen
AT danielsmj effectofnickelchlorideonprimaryantibodyproductioninthespleen
AT coffindl effectofnickelchlorideonprimaryantibodyproductioninthespleen

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