The role of biotransformation in chemical-induced liver injury.

The role of drug metabolism in chemical-induced liver injury is reviewed. Parameters for studying the formation of chemically reactive metabolites are discussed and the factors that alter the formation and covalent binding of reactive metabolites are selectively emphasized. Some of the experimental...

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Detalles Bibliográficos
Autores principales: Mitchell, J R, Snodgrass, W R, Gillette, J R
Formato: Texto
Lenguaje:English
Publicado: 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475156/
https://www.ncbi.nlm.nih.gov/pubmed/1033831
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author Mitchell, J R
Snodgrass, W R
Gillette, J R
author_facet Mitchell, J R
Snodgrass, W R
Gillette, J R
author_sort Mitchell, J R
collection PubMed
description The role of drug metabolism in chemical-induced liver injury is reviewed. Parameters for studying the formation of chemically reactive metabolites are discussed and the factors that alter the formation and covalent binding of reactive metabolites are selectively emphasized. Some of the experimental work that led to these concepts is discussed, especially the chemical toxicology of the hepatic injury produced by acetaminophen, bromobenzene, furosemide, isoniazid and iproniazid.
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spelling pubmed-14751562006-06-09 The role of biotransformation in chemical-induced liver injury. Mitchell, J R Snodgrass, W R Gillette, J R Environ Health Perspect Research Article The role of drug metabolism in chemical-induced liver injury is reviewed. Parameters for studying the formation of chemically reactive metabolites are discussed and the factors that alter the formation and covalent binding of reactive metabolites are selectively emphasized. Some of the experimental work that led to these concepts is discussed, especially the chemical toxicology of the hepatic injury produced by acetaminophen, bromobenzene, furosemide, isoniazid and iproniazid. 1976-06 /pmc/articles/PMC1475156/ /pubmed/1033831 Text en
spellingShingle Research Article
Mitchell, J R
Snodgrass, W R
Gillette, J R
The role of biotransformation in chemical-induced liver injury.
title The role of biotransformation in chemical-induced liver injury.
title_full The role of biotransformation in chemical-induced liver injury.
title_fullStr The role of biotransformation in chemical-induced liver injury.
title_full_unstemmed The role of biotransformation in chemical-induced liver injury.
title_short The role of biotransformation in chemical-induced liver injury.
title_sort role of biotransformation in chemical-induced liver injury.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475156/
https://www.ncbi.nlm.nih.gov/pubmed/1033831
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AT gillettejr roleofbiotransformationinchemicalinducedliverinjury

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