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Factors influencing the deposition of inhaled particles.

Because the initial deposition pattern of inhaled particles of various toxic agents determines their future clearance and insult to tissue, respiratory tract deposition is important in assessing the potential toxicity of inhaled aerosols. Factors influencing the deposition of inhaled particles can b...

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Detalles Bibliográficos
Autores principales: Yeh, H C, Phalen, R F, Raabe, O G
Formato: Texto
Lenguaje:English
Publicado: 1976
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475169/
https://www.ncbi.nlm.nih.gov/pubmed/1001293
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author Yeh, H C
Phalen, R F
Raabe, O G
author_facet Yeh, H C
Phalen, R F
Raabe, O G
author_sort Yeh, H C
collection PubMed
description Because the initial deposition pattern of inhaled particles of various toxic agents determines their future clearance and insult to tissue, respiratory tract deposition is important in assessing the potential toxicity of inhaled aerosols. Factors influencing the deposition of inhaled particles can be classified into three main areas: (1) the physics of aerosols, (2) the anatomy of the respiratory tract and (3) the airflow patterns in the lung airways. In the physics of aerosols, the forces acting on a particle and its physical and chemical properties, such as particle size or size distribution, density, shape, hygroscopic or hydrophobic character, and chemical reactions of the particle will affect the deposition. With respect to the anatomy of the respiratory tract, important parameters are the diameters, the lengths, and the branching angles of airway segments, which determine the deposition. Physiological factors include airflow and breathing patterns, which influence particle deposition. Various lung models used in predicting particle deposition are reviewed and discussed. The air-way structures of various animal species are compared, showing the unique structure of the human lung compared to the animal species under study. Regional deposition data in man and dog are reviewed. Recent deposition data for small rodents are presented, showing regional difference in deposition with the right apical lobe having the highest relative deposition.
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spelling pubmed-14751692006-06-09 Factors influencing the deposition of inhaled particles. Yeh, H C Phalen, R F Raabe, O G Environ Health Perspect Research Article Because the initial deposition pattern of inhaled particles of various toxic agents determines their future clearance and insult to tissue, respiratory tract deposition is important in assessing the potential toxicity of inhaled aerosols. Factors influencing the deposition of inhaled particles can be classified into three main areas: (1) the physics of aerosols, (2) the anatomy of the respiratory tract and (3) the airflow patterns in the lung airways. In the physics of aerosols, the forces acting on a particle and its physical and chemical properties, such as particle size or size distribution, density, shape, hygroscopic or hydrophobic character, and chemical reactions of the particle will affect the deposition. With respect to the anatomy of the respiratory tract, important parameters are the diameters, the lengths, and the branching angles of airway segments, which determine the deposition. Physiological factors include airflow and breathing patterns, which influence particle deposition. Various lung models used in predicting particle deposition are reviewed and discussed. The air-way structures of various animal species are compared, showing the unique structure of the human lung compared to the animal species under study. Regional deposition data in man and dog are reviewed. Recent deposition data for small rodents are presented, showing regional difference in deposition with the right apical lobe having the highest relative deposition. 1976-06 /pmc/articles/PMC1475169/ /pubmed/1001293 Text en
spellingShingle Research Article
Yeh, H C
Phalen, R F
Raabe, O G
Factors influencing the deposition of inhaled particles.
title Factors influencing the deposition of inhaled particles.
title_full Factors influencing the deposition of inhaled particles.
title_fullStr Factors influencing the deposition of inhaled particles.
title_full_unstemmed Factors influencing the deposition of inhaled particles.
title_short Factors influencing the deposition of inhaled particles.
title_sort factors influencing the deposition of inhaled particles.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475169/
https://www.ncbi.nlm.nih.gov/pubmed/1001293
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