Pulmonary response to polyurethane dust.

Weanling and 9 months or older rats were exposed to particles of an aged (PUF I) or freshly prepared (PUF II) rigid polyurethane foam by intratracheal intubation. The dose was 5 mg of particles. The response of the lung tissue was examined morphologically by serial sacrifices. Inflammation and macro...

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Detalles Bibliográficos
Autores principales: Stemmer, K L, Bingham, E, Barkley, W
Formato: Texto
Lenguaje:English
Publicado: 1975
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475184/
https://www.ncbi.nlm.nih.gov/pubmed/1175548
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author Stemmer, K L
Bingham, E
Barkley, W
author_facet Stemmer, K L
Bingham, E
Barkley, W
author_sort Stemmer, K L
collection PubMed
description Weanling and 9 months or older rats were exposed to particles of an aged (PUF I) or freshly prepared (PUF II) rigid polyurethane foam by intratracheal intubation. The dose was 5 mg of particles. The response of the lung tissue was examined morphologically by serial sacrifices. Inflammation and macrophage activity were the initial responses. Fibrosis developed after 6 months. Nodular scars and perifocal emphysema were seen after 12 months. Four rats had a papillary adenoma in a major bronchus after 18 months exposure to PUF II.
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spelling pubmed-14751842006-06-09 Pulmonary response to polyurethane dust. Stemmer, K L Bingham, E Barkley, W Environ Health Perspect Research Article Weanling and 9 months or older rats were exposed to particles of an aged (PUF I) or freshly prepared (PUF II) rigid polyurethane foam by intratracheal intubation. The dose was 5 mg of particles. The response of the lung tissue was examined morphologically by serial sacrifices. Inflammation and macrophage activity were the initial responses. Fibrosis developed after 6 months. Nodular scars and perifocal emphysema were seen after 12 months. Four rats had a papillary adenoma in a major bronchus after 18 months exposure to PUF II. 1975-06 /pmc/articles/PMC1475184/ /pubmed/1175548 Text en
spellingShingle Research Article
Stemmer, K L
Bingham, E
Barkley, W
Pulmonary response to polyurethane dust.
title Pulmonary response to polyurethane dust.
title_full Pulmonary response to polyurethane dust.
title_fullStr Pulmonary response to polyurethane dust.
title_full_unstemmed Pulmonary response to polyurethane dust.
title_short Pulmonary response to polyurethane dust.
title_sort pulmonary response to polyurethane dust.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475184/
https://www.ncbi.nlm.nih.gov/pubmed/1175548
work_keys_str_mv AT stemmerkl pulmonaryresponsetopolyurethanedust
AT binghame pulmonaryresponsetopolyurethanedust
AT barkleyw pulmonaryresponsetopolyurethanedust

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