Regulation of Mitotic Inhibitor Mik1 Helps to Enforce the DNA Damage Checkpoint

The protein kinase Chk1 enforces the DNA damage checkpoint. This checkpoint delays mitosis until damaged DNA is repaired. Chk1 regulates the activity and localization of Cdc25, the tyrosine phosphatase that activates the cdk Cdc2. Here we report that Mik1, a tyrosine kinase that inhibits Cdc2, is po...

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Detalles Bibliográficos
Autores principales: Baber-Furnari, Beth A., Rhind, Nick, Boddy, Michael N., Shanahan, Paul, Lopez-Girona, Antonia, Russell, Paul
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2000
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC14752/
https://www.ncbi.nlm.nih.gov/pubmed/10637286

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