Cargando…

Dose-dependent fate of vinyl chloride and its possible relationship to oncogenicity in rats.

Studies on the fate of 14C-labeled vinyl chloride (VC) following oral administration and inhalation exposure in rats demonstrated that the disposition of VC in the body is a function of the dose. More importantly, from the data available, it appears that a correlation exists between doses of VC whic...

Descripción completa

Detalles Bibliográficos
Autores principales: Watanabe, P G, Gehring, P J
Formato: Texto
Lenguaje:English
Publicado: 1976
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475244/
https://www.ncbi.nlm.nih.gov/pubmed/1026400
_version_ 1782128060902932480
author Watanabe, P G
Gehring, P J
author_facet Watanabe, P G
Gehring, P J
author_sort Watanabe, P G
collection PubMed
description Studies on the fate of 14C-labeled vinyl chloride (VC) following oral administration and inhalation exposure in rats demonstrated that the disposition of VC in the body is a function of the dose. More importantly, from the data available, it appears that a correlation exists between doses of VC which cause tumors and those that saturate metabolic or detoxifying pathways. Additional studies characterized the depression of liver non-protein sulfhydryl content (primarily GSH) with the duration and concentration of exposure to VC. The results of these investigations indicate that statistical projections utilizing data collected from rats exposed to high doses of VC are invalid for predicting the hazard of low level exposure, because such projections violate a priori assumption that the dynamics governing the fate of VC in the body are unaltered.
format Text
id pubmed-1475244
institution National Center for Biotechnology Information
language English
publishDate 1976
record_format MEDLINE/PubMed
spelling pubmed-14752442006-06-09 Dose-dependent fate of vinyl chloride and its possible relationship to oncogenicity in rats. Watanabe, P G Gehring, P J Environ Health Perspect Research Article Studies on the fate of 14C-labeled vinyl chloride (VC) following oral administration and inhalation exposure in rats demonstrated that the disposition of VC in the body is a function of the dose. More importantly, from the data available, it appears that a correlation exists between doses of VC which cause tumors and those that saturate metabolic or detoxifying pathways. Additional studies characterized the depression of liver non-protein sulfhydryl content (primarily GSH) with the duration and concentration of exposure to VC. The results of these investigations indicate that statistical projections utilizing data collected from rats exposed to high doses of VC are invalid for predicting the hazard of low level exposure, because such projections violate a priori assumption that the dynamics governing the fate of VC in the body are unaltered. 1976-10 /pmc/articles/PMC1475244/ /pubmed/1026400 Text en
spellingShingle Research Article
Watanabe, P G
Gehring, P J
Dose-dependent fate of vinyl chloride and its possible relationship to oncogenicity in rats.
title Dose-dependent fate of vinyl chloride and its possible relationship to oncogenicity in rats.
title_full Dose-dependent fate of vinyl chloride and its possible relationship to oncogenicity in rats.
title_fullStr Dose-dependent fate of vinyl chloride and its possible relationship to oncogenicity in rats.
title_full_unstemmed Dose-dependent fate of vinyl chloride and its possible relationship to oncogenicity in rats.
title_short Dose-dependent fate of vinyl chloride and its possible relationship to oncogenicity in rats.
title_sort dose-dependent fate of vinyl chloride and its possible relationship to oncogenicity in rats.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475244/
https://www.ncbi.nlm.nih.gov/pubmed/1026400
work_keys_str_mv AT watanabepg dosedependentfateofvinylchlorideanditspossiblerelationshiptooncogenicityinrats
AT gehringpj dosedependentfateofvinylchlorideanditspossiblerelationshiptooncogenicityinrats