Mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane.

The presumed halothane metabolite, 2-bromo-1,1-difluoroethylene, produces both base substitution and frameshift mutations in Salmonella typhimurium. Direct mutagenesis of isolated DNA also was observed by using a Bacillus subtils transformation assay to score the production of mutagenic lesions in t...

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Detalles Bibliográficos
Autores principales: Garro, A J, Phillips, R A
Formato: Texto
Lenguaje:English
Publicado: 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475352/
https://www.ncbi.nlm.nih.gov/pubmed/417917
Descripción
Sumario:The presumed halothane metabolite, 2-bromo-1,1-difluoroethylene, produces both base substitution and frameshift mutations in Salmonella typhimurium. Direct mutagenesis of isolated DNA also was observed by using a Bacillus subtils transformation assay to score the production of mutagenic lesions in transforming DNA.

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