Mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane.

The presumed halothane metabolite, 2-bromo-1,1-difluoroethylene, produces both base substitution and frameshift mutations in Salmonella typhimurium. Direct mutagenesis of isolated DNA also was observed by using a Bacillus subtils transformation assay to score the production of mutagenic lesions in t...

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Detalles Bibliográficos
Autores principales: Garro, A J, Phillips, R A
Formato: Texto
Lenguaje:English
Publicado: 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475352/
https://www.ncbi.nlm.nih.gov/pubmed/417917
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author Garro, A J
Phillips, R A
author_facet Garro, A J
Phillips, R A
author_sort Garro, A J
collection PubMed
description The presumed halothane metabolite, 2-bromo-1,1-difluoroethylene, produces both base substitution and frameshift mutations in Salmonella typhimurium. Direct mutagenesis of isolated DNA also was observed by using a Bacillus subtils transformation assay to score the production of mutagenic lesions in transforming DNA.
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spelling pubmed-14753522006-06-11 Mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane. Garro, A J Phillips, R A Environ Health Perspect Research Article The presumed halothane metabolite, 2-bromo-1,1-difluoroethylene, produces both base substitution and frameshift mutations in Salmonella typhimurium. Direct mutagenesis of isolated DNA also was observed by using a Bacillus subtils transformation assay to score the production of mutagenic lesions in transforming DNA. 1977-12 /pmc/articles/PMC1475352/ /pubmed/417917 Text en
spellingShingle Research Article
Garro, A J
Phillips, R A
Mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane.
title Mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane.
title_full Mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane.
title_fullStr Mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane.
title_full_unstemmed Mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane.
title_short Mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane.
title_sort mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475352/
https://www.ncbi.nlm.nih.gov/pubmed/417917
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AT phillipsra mutagenicityofthehalogenatedolefin2bromo2chloro11difluoroethyleneapresumedmetaboliteoftheinhalationanesthetichalothane

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