Effect of various treatments on toxicity of inhaled vinylidene chloride.

The toxicity of vinylidene chloride (VDC) was studied in mice and rats exposed to various concentrations of the vapors for 23 hr/day. In addition, the ability of various treatments to alter parameters of toxicity was evaluated. Mice were more sensitive than rats both to the acute lethal and hepatoto...

Descripción completa

Detalles Bibliográficos
Autores principales: Short, R D, Winston, J M, Minor, J L, Seifter, J, Lee, C C
Formato: Texto
Lenguaje:English
Publicado: 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475354/
https://www.ncbi.nlm.nih.gov/pubmed/612437
_version_ 1782128086159982592
author Short, R D
Winston, J M
Minor, J L
Seifter, J
Lee, C C
author_facet Short, R D
Winston, J M
Minor, J L
Seifter, J
Lee, C C
author_sort Short, R D
collection PubMed
description The toxicity of vinylidene chloride (VDC) was studied in mice and rats exposed to various concentrations of the vapors for 23 hr/day. In addition, the ability of various treatments to alter parameters of toxicity was evaluated. Mice were more sensitive than rats both to the acute lethal and hepatotoxic effects of VDC. Disulfiram treatment reduced the acute lethal and hepatotoxic effects of inhaled VDC and reduced the levels of covalent bound radioactivity in the liver and kidney after the intraperitoneal administration of 14C-VDC. Treatment with diethyldithiocarbamate and thiram also protected mice from the acute lethal effects of VDC.
format Text
id pubmed-1475354
institution National Center for Biotechnology Information
language English
publishDate 1977
record_format MEDLINE/PubMed
spelling pubmed-14753542006-06-11 Effect of various treatments on toxicity of inhaled vinylidene chloride. Short, R D Winston, J M Minor, J L Seifter, J Lee, C C Environ Health Perspect Research Article The toxicity of vinylidene chloride (VDC) was studied in mice and rats exposed to various concentrations of the vapors for 23 hr/day. In addition, the ability of various treatments to alter parameters of toxicity was evaluated. Mice were more sensitive than rats both to the acute lethal and hepatotoxic effects of VDC. Disulfiram treatment reduced the acute lethal and hepatotoxic effects of inhaled VDC and reduced the levels of covalent bound radioactivity in the liver and kidney after the intraperitoneal administration of 14C-VDC. Treatment with diethyldithiocarbamate and thiram also protected mice from the acute lethal effects of VDC. 1977-12 /pmc/articles/PMC1475354/ /pubmed/612437 Text en
spellingShingle Research Article
Short, R D
Winston, J M
Minor, J L
Seifter, J
Lee, C C
Effect of various treatments on toxicity of inhaled vinylidene chloride.
title Effect of various treatments on toxicity of inhaled vinylidene chloride.
title_full Effect of various treatments on toxicity of inhaled vinylidene chloride.
title_fullStr Effect of various treatments on toxicity of inhaled vinylidene chloride.
title_full_unstemmed Effect of various treatments on toxicity of inhaled vinylidene chloride.
title_short Effect of various treatments on toxicity of inhaled vinylidene chloride.
title_sort effect of various treatments on toxicity of inhaled vinylidene chloride.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475354/
https://www.ncbi.nlm.nih.gov/pubmed/612437
work_keys_str_mv AT shortrd effectofvarioustreatmentsontoxicityofinhaledvinylidenechloride
AT winstonjm effectofvarioustreatmentsontoxicityofinhaledvinylidenechloride
AT minorjl effectofvarioustreatmentsontoxicityofinhaledvinylidenechloride
AT seifterj effectofvarioustreatmentsontoxicityofinhaledvinylidenechloride
AT leecc effectofvarioustreatmentsontoxicityofinhaledvinylidenechloride

Ejemplares similares