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Cytotoxicity of heated chrysotile
Cytotoxicity and hemolysis were studied in chrysotile and quartz. The biological activity of the surface seemed to be different between chrysotile and quartz. Quartz lost its cytotoxicity on heating over about 500°C. However chrysotile showed remarkable toxicity and induced hemolysis on heating betw...
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Formato: | Texto |
Lenguaje: | English |
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1974
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475415/ https://www.ncbi.nlm.nih.gov/pubmed/4470944 |
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author | Hayashi, Hisato |
author_facet | Hayashi, Hisato |
author_sort | Hayashi, Hisato |
collection | PubMed |
description | Cytotoxicity and hemolysis were studied in chrysotile and quartz. The biological activity of the surface seemed to be different between chrysotile and quartz. Quartz lost its cytotoxicity on heating over about 500°C. However chrysotile showed remarkable toxicity and induced hemolysis on heating between 650 and 800°C, compared with the original unheated specimens. The mice injected intraperitoneally with minerals heated in this temperature range generally died within 48 hr after injection, while those injected with untreated chrysotile or chrysotile heated in the other heat ranges did not. The products in this range were highly disorded materials. It was assumed that the change of biological effects resulting from heat treatment may be related to the disordered state of chrysotile in the process of transformation into forsterite. The relationship between chemical character and cytotoxicity of the heated chrysotile specimens was also studied. |
format | Text |
id | pubmed-1475415 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1974 |
record_format | MEDLINE/PubMed |
spelling | pubmed-14754152006-06-09 Cytotoxicity of heated chrysotile Hayashi, Hisato Environ Health Perspect Articles Cytotoxicity and hemolysis were studied in chrysotile and quartz. The biological activity of the surface seemed to be different between chrysotile and quartz. Quartz lost its cytotoxicity on heating over about 500°C. However chrysotile showed remarkable toxicity and induced hemolysis on heating between 650 and 800°C, compared with the original unheated specimens. The mice injected intraperitoneally with minerals heated in this temperature range generally died within 48 hr after injection, while those injected with untreated chrysotile or chrysotile heated in the other heat ranges did not. The products in this range were highly disorded materials. It was assumed that the change of biological effects resulting from heat treatment may be related to the disordered state of chrysotile in the process of transformation into forsterite. The relationship between chemical character and cytotoxicity of the heated chrysotile specimens was also studied. 1974-12 /pmc/articles/PMC1475415/ /pubmed/4470944 Text en |
spellingShingle | Articles Hayashi, Hisato Cytotoxicity of heated chrysotile |
title | Cytotoxicity of heated chrysotile |
title_full | Cytotoxicity of heated chrysotile |
title_fullStr | Cytotoxicity of heated chrysotile |
title_full_unstemmed | Cytotoxicity of heated chrysotile |
title_short | Cytotoxicity of heated chrysotile |
title_sort | cytotoxicity of heated chrysotile |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475415/ https://www.ncbi.nlm.nih.gov/pubmed/4470944 |
work_keys_str_mv | AT hayashihisato cytotoxicityofheatedchrysotile |