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The retrovirus RNA trafficking granule: from birth to maturity
Post-transcriptional events in the life of an RNA including RNA processing, transport, translation and metabolism are characterized by the regulated assembly of multiple ribonucleoprotein (RNP) complexes. At each of these steps, there is the engagement and disengagement of RNA-binding proteins until...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475878/ https://www.ncbi.nlm.nih.gov/pubmed/16545126 http://dx.doi.org/10.1186/1742-4690-3-18 |
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author | Cochrane, Alan W McNally, Mark T Mouland, Andrew J |
author_facet | Cochrane, Alan W McNally, Mark T Mouland, Andrew J |
author_sort | Cochrane, Alan W |
collection | PubMed |
description | Post-transcriptional events in the life of an RNA including RNA processing, transport, translation and metabolism are characterized by the regulated assembly of multiple ribonucleoprotein (RNP) complexes. At each of these steps, there is the engagement and disengagement of RNA-binding proteins until the RNA reaches its final destination. For retroviral genomic RNA, the final destination is the capsid. Numerous studies have provided crucial information about these processes and serve as the basis for studies on the intracellular fate of retroviral RNA. Retroviral RNAs are like cellular mRNAs but their processing is more tightly regulated by multiple cis-acting sequences and the activities of many trans-acting proteins. This review describes the viral and cellular partners that retroviral RNA encounters during its maturation that begins in the nucleus, focusing on important events including splicing, 3' end-processing, RNA trafficking from the nucleus to the cytoplasm and finally, mechanisms that lead to its compartmentalization into progeny virions. |
format | Text |
id | pubmed-1475878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-14758782006-06-10 The retrovirus RNA trafficking granule: from birth to maturity Cochrane, Alan W McNally, Mark T Mouland, Andrew J Retrovirology Review Post-transcriptional events in the life of an RNA including RNA processing, transport, translation and metabolism are characterized by the regulated assembly of multiple ribonucleoprotein (RNP) complexes. At each of these steps, there is the engagement and disengagement of RNA-binding proteins until the RNA reaches its final destination. For retroviral genomic RNA, the final destination is the capsid. Numerous studies have provided crucial information about these processes and serve as the basis for studies on the intracellular fate of retroviral RNA. Retroviral RNAs are like cellular mRNAs but their processing is more tightly regulated by multiple cis-acting sequences and the activities of many trans-acting proteins. This review describes the viral and cellular partners that retroviral RNA encounters during its maturation that begins in the nucleus, focusing on important events including splicing, 3' end-processing, RNA trafficking from the nucleus to the cytoplasm and finally, mechanisms that lead to its compartmentalization into progeny virions. BioMed Central 2006-03-17 /pmc/articles/PMC1475878/ /pubmed/16545126 http://dx.doi.org/10.1186/1742-4690-3-18 Text en Copyright © 2006 Cochrane et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Cochrane, Alan W McNally, Mark T Mouland, Andrew J The retrovirus RNA trafficking granule: from birth to maturity |
title | The retrovirus RNA trafficking granule: from birth to maturity |
title_full | The retrovirus RNA trafficking granule: from birth to maturity |
title_fullStr | The retrovirus RNA trafficking granule: from birth to maturity |
title_full_unstemmed | The retrovirus RNA trafficking granule: from birth to maturity |
title_short | The retrovirus RNA trafficking granule: from birth to maturity |
title_sort | retrovirus rna trafficking granule: from birth to maturity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475878/ https://www.ncbi.nlm.nih.gov/pubmed/16545126 http://dx.doi.org/10.1186/1742-4690-3-18 |
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