A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis

Aging is associated with a paradox of immunodeficiency and inflammation (an evidence of hyperactive immune system). Apoptosis is associated with cellular depletion and suppression of inflammatory response. In this brief review, we will present evidence for the role of increased apoptosis in immunode...

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Autores principales: Gupta, Sudhir, Agrawal, Anshu, Agrawal, Sudhanshu, Su, Houfen, Gollapudi, Sastry
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475884/
https://www.ncbi.nlm.nih.gov/pubmed/16712718
http://dx.doi.org/10.1186/1742-4933-3-5
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author Gupta, Sudhir
Agrawal, Anshu
Agrawal, Sudhanshu
Su, Houfen
Gollapudi, Sastry
author_facet Gupta, Sudhir
Agrawal, Anshu
Agrawal, Sudhanshu
Su, Houfen
Gollapudi, Sastry
author_sort Gupta, Sudhir
collection PubMed
description Aging is associated with a paradox of immunodeficiency and inflammation (an evidence of hyperactive immune system). Apoptosis is associated with cellular depletion and suppression of inflammatory response. In this brief review, we will present evidence for the role of increased apoptosis in immunodeficiency and paradoxical increased inflammation associated with human aging. In particular, a role of apoptotic cells in failure to generate anti-inflammatory responses and directly activating inflammatory responses will be discussed.
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spelling pubmed-14758842006-06-10 A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis Gupta, Sudhir Agrawal, Anshu Agrawal, Sudhanshu Su, Houfen Gollapudi, Sastry Immun Ageing Review Aging is associated with a paradox of immunodeficiency and inflammation (an evidence of hyperactive immune system). Apoptosis is associated with cellular depletion and suppression of inflammatory response. In this brief review, we will present evidence for the role of increased apoptosis in immunodeficiency and paradoxical increased inflammation associated with human aging. In particular, a role of apoptotic cells in failure to generate anti-inflammatory responses and directly activating inflammatory responses will be discussed. BioMed Central 2006-05-19 /pmc/articles/PMC1475884/ /pubmed/16712718 http://dx.doi.org/10.1186/1742-4933-3-5 Text en Copyright © 2006 Gupta et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Gupta, Sudhir
Agrawal, Anshu
Agrawal, Sudhanshu
Su, Houfen
Gollapudi, Sastry
A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis
title A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis
title_full A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis
title_fullStr A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis
title_full_unstemmed A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis
title_short A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis
title_sort paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475884/
https://www.ncbi.nlm.nih.gov/pubmed/16712718
http://dx.doi.org/10.1186/1742-4933-3-5
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