Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator

BACKGROUND: Urokinase-type plasminogen activator (uPA) plays a major role in extracellular proteolytic events associated with tumor cell growth, migration and angiogenesis. Consequently, uPA is an attractive target for the development of small molecule active site inhibitors. Most of the recent drug...

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Detalles Bibliográficos
Autores principales: Heynekamp, Justin J, Hunsaker, Lucy A, Vander Jagt, Thomas A, Deck, Lorraine M, Vander Jagt, David L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479381/
https://www.ncbi.nlm.nih.gov/pubmed/16466576
http://dx.doi.org/10.1186/1472-6769-6-1

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