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Topiramate in the treatment of compulsive sexual behavior: case report

BACKGROUND: Among the multiple mechanisms of action of topiramate, AMPA/kainate antagonism may be particularly interesting for the treatment of disorders characterized by conditioned cognitive and behavioral cue reactivity. CASE PRESENTATION: We report the case of a patient consulting primarily for...

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Detalles Bibliográficos
Autores principales: Khazaal, Yasser, Zullino, Daniele Fabio
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479803/
https://www.ncbi.nlm.nih.gov/pubmed/16719909
http://dx.doi.org/10.1186/1471-244X-6-22
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author Khazaal, Yasser
Zullino, Daniele Fabio
author_facet Khazaal, Yasser
Zullino, Daniele Fabio
author_sort Khazaal, Yasser
collection PubMed
description BACKGROUND: Among the multiple mechanisms of action of topiramate, AMPA/kainate antagonism may be particularly interesting for the treatment of disorders characterized by conditioned cognitive and behavioral cue reactivity. CASE PRESENTATION: We report the case of a patient consulting primarily for obesity and cue triggered snacking, who responded well on topiramate at doses up to 50 mg. Coincidentally he reported on an improvement of compulsive nonparaphilic sexual behaviors (consumption of prostitution), which was also strongly triggered by environmental cues. Both addictive behaviors (snacking and consumption of prostitution) reoccurred after discontinuation of topiramate and again responded reintroduction of the drug. CONCLUSION: The present case report of topiramate's effect on comorbid obesity and nonparaphilic addiction could be interpreted as a further indication that topiramate acts on the common pathway underlying conditioned behaviors and seems to be a treatment of behavioral disorders associated with environmental cues.
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spelling pubmed-14798032006-06-17 Topiramate in the treatment of compulsive sexual behavior: case report Khazaal, Yasser Zullino, Daniele Fabio BMC Psychiatry Case Report BACKGROUND: Among the multiple mechanisms of action of topiramate, AMPA/kainate antagonism may be particularly interesting for the treatment of disorders characterized by conditioned cognitive and behavioral cue reactivity. CASE PRESENTATION: We report the case of a patient consulting primarily for obesity and cue triggered snacking, who responded well on topiramate at doses up to 50 mg. Coincidentally he reported on an improvement of compulsive nonparaphilic sexual behaviors (consumption of prostitution), which was also strongly triggered by environmental cues. Both addictive behaviors (snacking and consumption of prostitution) reoccurred after discontinuation of topiramate and again responded reintroduction of the drug. CONCLUSION: The present case report of topiramate's effect on comorbid obesity and nonparaphilic addiction could be interpreted as a further indication that topiramate acts on the common pathway underlying conditioned behaviors and seems to be a treatment of behavioral disorders associated with environmental cues. BioMed Central 2006-05-23 /pmc/articles/PMC1479803/ /pubmed/16719909 http://dx.doi.org/10.1186/1471-244X-6-22 Text en Copyright © 2006 Khazaal and Zullino; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Khazaal, Yasser
Zullino, Daniele Fabio
Topiramate in the treatment of compulsive sexual behavior: case report
title Topiramate in the treatment of compulsive sexual behavior: case report
title_full Topiramate in the treatment of compulsive sexual behavior: case report
title_fullStr Topiramate in the treatment of compulsive sexual behavior: case report
title_full_unstemmed Topiramate in the treatment of compulsive sexual behavior: case report
title_short Topiramate in the treatment of compulsive sexual behavior: case report
title_sort topiramate in the treatment of compulsive sexual behavior: case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479803/
https://www.ncbi.nlm.nih.gov/pubmed/16719909
http://dx.doi.org/10.1186/1471-244X-6-22
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