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LINE-1 Hypomethylation in a Choline-Deficiency-Induced Liver Cancer in Rats: Dependence on Feeding Period

Chronic feeding of methyl-donor (methionine, choline, folic acid, and vitamin B12) deficient diet induces hepatocellular carcinoma formation in rats. Previous studies have shown that promoter CpG islands in various cancer-related genes are aberrantly methylated in this model. Moreover, the global ge...

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Detalles Bibliográficos
Autores principales:	Asada, Kiyoshi, Kotake, Yashige, Asada, Rumiko, Saunders, Deborah, Broyles, Robert H., Towner, Rheal A., Fukui, Hiroshi, Floyd, Robert A.
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2006
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479888/ https://www.ncbi.nlm.nih.gov/pubmed/16877811 http://dx.doi.org/10.1155/JBB/2006/17142

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