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Reversible inactivation of the transcriptional function of P53 protein by farnesylation

BACKGROUND: The use of integrating viral vectors in Gene therapy clinical trials has pointed out the problem of the deleterous effect of the integration of the ectopic gene to the cellular genome and the safety of this strategy. We proposed here a way to induce the death of gene modified cells upon...

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Detalles Bibliográficos
Autores principales:	Couderc, Bettina, Penary, Marie, Tohfe, Mustapha, Pradines, Anne, Casteignau, Antoine, Berg, Danièle, Favre, Gilles
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2006
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1481662/ https://www.ncbi.nlm.nih.gov/pubmed/16732889 http://dx.doi.org/10.1186/1472-6750-6-26

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