Activation of protein kinase C in the spinal cord produces mechanical hyperalgesia by activating glutamate receptors, but does not mediate chronic muscle-induced hyperalgesia

BACKGROUND: Protein kinase C (PKC) in the spinal cord appears to mediate chronic injury-induced pain, but not acute nociceptive pain. Muscle insult results in increased release of glutamate spinally, and hyperalgesia that is reversed by spinal blockade of NMDA and non-NMDA glutamate receptors. There...

Descripción completa

Detalles Bibliográficos
Autores principales: Sluka, KA, Audette, KM
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482680/
https://www.ncbi.nlm.nih.gov/pubmed/16584564
http://dx.doi.org/10.1186/1744-8069-2-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482680/
https://www.ncbi.nlm.nih.gov/pubmed/16584564
http://dx.doi.org/10.1186/1744-8069-2-13

Ejemplares similares