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Estrogen-like activity of seafood related to environmental chemical contaminants

BACKGROUND: A wide variety of environmental pollutants occur in surface waters, including estuarine and marine waters. Many of these contaminants are recognised as endocrine disrupting chemicals (EDCs) which can adversely affect the male and female reproductive system by binding the estrogen recepto...

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Autores principales: Garritano, Sonia, Pinto, Barbara, Calderisi, Marco, Cirillo, Teresa, Amodio-Cocchieri, Renata, Reali, Daniela
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1484473/
https://www.ncbi.nlm.nih.gov/pubmed/16573822
http://dx.doi.org/10.1186/1476-069X-5-9
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author Garritano, Sonia
Pinto, Barbara
Calderisi, Marco
Cirillo, Teresa
Amodio-Cocchieri, Renata
Reali, Daniela
author_facet Garritano, Sonia
Pinto, Barbara
Calderisi, Marco
Cirillo, Teresa
Amodio-Cocchieri, Renata
Reali, Daniela
author_sort Garritano, Sonia
collection PubMed
description BACKGROUND: A wide variety of environmental pollutants occur in surface waters, including estuarine and marine waters. Many of these contaminants are recognised as endocrine disrupting chemicals (EDCs) which can adversely affect the male and female reproductive system by binding the estrogen receptor and exhibiting hormone-like activities. In this study the estrogenic activity of extracts of edible marine organisms for human consumption from the Mediterranean Sea was assayed. METHODS: Marine organisms were collected in two different areas of the Mediterranean Sea. The estrogenic activity of tissues was assessed using an in vitro yeast reporter gene assay (S. cerevisiae RMY 326 ER-ERE). Concentrations of polychlorinated biphenyls (PCBs) (congeners 28, 52, 101, 118, 138, 153, 180) in fish tissue was also evaluated. RESULTS: Thirty-eight percent of extracts showed a hormone-like activity higher than 10% of the activity elicited by 10 nM 17b-estradiol (E2) used as control. Total PCB concentrations ranged from 0.002 up to 1.785 ng/g wet weight. Chemical analyses detected different levels of contamination among the species collected in the two areas, with the ones collected in the Adriatic Sea showing concentrations significantly higher than those collected in the Tyrrhenian Sea (p < 0.01). CONCLUSION: The more frequent combination of chemicals in the samples that showed higher estrogenic activity was PCB 28, PCB 101, PCB 153, PCB 180. The content of PCBs and estrogenic activity did not reveal any significant correlation.
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spelling pubmed-14844732006-07-01 Estrogen-like activity of seafood related to environmental chemical contaminants Garritano, Sonia Pinto, Barbara Calderisi, Marco Cirillo, Teresa Amodio-Cocchieri, Renata Reali, Daniela Environ Health Research BACKGROUND: A wide variety of environmental pollutants occur in surface waters, including estuarine and marine waters. Many of these contaminants are recognised as endocrine disrupting chemicals (EDCs) which can adversely affect the male and female reproductive system by binding the estrogen receptor and exhibiting hormone-like activities. In this study the estrogenic activity of extracts of edible marine organisms for human consumption from the Mediterranean Sea was assayed. METHODS: Marine organisms were collected in two different areas of the Mediterranean Sea. The estrogenic activity of tissues was assessed using an in vitro yeast reporter gene assay (S. cerevisiae RMY 326 ER-ERE). Concentrations of polychlorinated biphenyls (PCBs) (congeners 28, 52, 101, 118, 138, 153, 180) in fish tissue was also evaluated. RESULTS: Thirty-eight percent of extracts showed a hormone-like activity higher than 10% of the activity elicited by 10 nM 17b-estradiol (E2) used as control. Total PCB concentrations ranged from 0.002 up to 1.785 ng/g wet weight. Chemical analyses detected different levels of contamination among the species collected in the two areas, with the ones collected in the Adriatic Sea showing concentrations significantly higher than those collected in the Tyrrhenian Sea (p < 0.01). CONCLUSION: The more frequent combination of chemicals in the samples that showed higher estrogenic activity was PCB 28, PCB 101, PCB 153, PCB 180. The content of PCBs and estrogenic activity did not reveal any significant correlation. BioMed Central 2006-03-30 /pmc/articles/PMC1484473/ /pubmed/16573822 http://dx.doi.org/10.1186/1476-069X-5-9 Text en Copyright © 2006 Garritano et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Garritano, Sonia
Pinto, Barbara
Calderisi, Marco
Cirillo, Teresa
Amodio-Cocchieri, Renata
Reali, Daniela
Estrogen-like activity of seafood related to environmental chemical contaminants
title Estrogen-like activity of seafood related to environmental chemical contaminants
title_full Estrogen-like activity of seafood related to environmental chemical contaminants
title_fullStr Estrogen-like activity of seafood related to environmental chemical contaminants
title_full_unstemmed Estrogen-like activity of seafood related to environmental chemical contaminants
title_short Estrogen-like activity of seafood related to environmental chemical contaminants
title_sort estrogen-like activity of seafood related to environmental chemical contaminants
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1484473/
https://www.ncbi.nlm.nih.gov/pubmed/16573822
http://dx.doi.org/10.1186/1476-069X-5-9
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