Inhibition of histone deacetylation in 293GPG packaging cell line improves the production of self-inactivating MLV-derived retroviral vectors

BACKGROUND: Self-inactivating retroviral vectors (SIN) are often associated with very low titers. Promoter elements embedded within SIN designs may suppress transcription of packageable retroviral RNA which in turn results in titer reduction. We tested whether this dominant-negative effect involves...

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Detalles Bibliográficos
Autores principales: Jaalouk, Diana E, Crosato, Milena, Brodt, Pnina, Galipeau, Jacques
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1488828/
https://www.ncbi.nlm.nih.gov/pubmed/16603064
http://dx.doi.org/10.1186/1743-422X-3-27

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