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MG-132, an inhibitor of proteasomes and calpains, induced inhibition of oocyte maturation and aneuploidy in mouse oocytes

BACKGROUND: Although chromosome missegregation during oocyte maturation (OM) is a significant contributor to human morbidity and mortality, very little is known about the causes and mechanisms of aneuploidy. Several investigators have proposed that temporal perturbations during OM predispose oocytes...

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Detalles Bibliográficos
Autores principales: Mailhes, John B, Hilliard, Colette, Lowery, Mary, London, Steve N
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC149371/
https://www.ncbi.nlm.nih.gov/pubmed/12437781
http://dx.doi.org/10.1186/1475-9268-1-2