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Characteristic promoter hypermethylation signatures in male germ cell tumors

BACKGROUND: Human male germ cell tumors (GCTs) arise from undifferentiated primordial germ cells (PGCs), a stage in which extensive methylation reprogramming occurs. GCTs exhibit pluripotentality and are highly sensitive to cisplatin therapy. The molecular basis of germ cell (GC) transformation, dif...

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Detalles Bibliográficos
Autores principales:	Koul, Sanjay, Houldsworth, Jane, Mansukhani, Mahesh M, Donadio, Alessia, McKiernan, James M, Reuter, Victor E, Bosl, George J, Chaganti, Raju S, Murty, Vundavalli V
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2002
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC149411/ https://www.ncbi.nlm.nih.gov/pubmed/12495446 http://dx.doi.org/10.1186/1476-4598-1-8

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