Cargando…

Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer

The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ding, Xian-Zhong, Hennig, Rene, Adrian, Thomas E
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2003
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC149414/ https://www.ncbi.nlm.nih.gov/pubmed/12575899 http://dx.doi.org/10.1186/1476-4598-2-10

Ejemplares similares

Exploration of binding site pattern in arachidonic acid metabolizing enzymes, Cyclooxygenases and Lipoxygenases
por: Reddy, Kakularam Kumar, et al.
Publicado: (2015)

Regulated Spatial Distribution of Cyclooxygenases and Lipoxygenases in Crohn's Ulcer
por: Mao, Yao, et al.
Publicado: (2006)

Cyclooxygenase‐2 and 5‐Lipoxygenase in Dogs with Chronic Enteropathies
por: Dumusc, S.D., et al.
Publicado: (2014)

Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells
por: Ganesh, Radhakrishnan, et al.
Publicado: (2012)

Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity
por: Kutil, Zsofia, et al.
Publicado: (2014)

Computational analysis of eugenol inhibitory activity in lipoxygenase and cyclooxygenase pathways
por: das Chagas Pereira de Andrade, Francisco, et al.
Publicado: (2020)

Ketogenic diets attenuate cyclooxygenase and lipoxygenase gene expression in multiple sclerosis
por: Bock, Markus, et al.
Publicado: (2018)

Pancreatic Stellate Cells (PSCs) express Cyclooxygenase-2 (COX-2) and pancreatic cancer stimulates COX-2 in PSCs
por: Yoshida, Seiya, et al.
Publicado: (2005)

The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein
por: Maxis, Kelitha, et al.
Publicado: (2006)

Design, synthesis, and computational studies on dihydropyrimidine scaffolds as potential lipoxygenase inhibitors and cancer chemopreventive agents
por: Venugopala, Katharigatta N, et al.
Publicado: (2015)

Impact of Aspirin Eugenol Ester on Cyclooxygenase-1, Cyclooxygenase-2, C-Reactive Protein, Prothrombin and Arachidonate 5-Lipoxygenase in Healthy Rats
por: Ma, Ning, et al.
Publicado: (2017)

Human cytomegalovirus infection is correlated with enhanced cyclooxygenase-2 and 5-lipoxygenase protein expression in breast cancer
por: Costa, Helena, et al.
Publicado: (2019)

Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature Review
por: Gholamalizadeh, Maryam, et al.
Publicado: (2022)

The role of lipoxygenases in pathophysiology; new insights and future perspectives
por: Mashima, Ryuichi, et al.
Publicado: (2015)

Reversal of High dietary fructose-induced PPARα suppression by oral administration of lipoxygenase/cyclooxygenase inhibitors
por: Kelley, Glen L, et al.
Publicado: (2005)

An unprecedented antioxidative isopimarane norditerpenoid from bivalve clam, Paphia malabarica with anti-cyclooxygenase and lipoxygenase potential
por: Joy, Minju, et al.
Publicado: (2017)

The role of chemoprevention by selective cyclooxygenase-2 inhibitors in colorectal cancer patients - a population-based study
por: Yang, Yi-Hsin, et al.
Publicado: (2012)

Zileuton, 5-Lipoxygenase Inhibitor, Acts as a Chemopreventive Agent in Intestinal Polyposis, by Modulating Polyp and Systemic Inflammation
por: Gounaris, Elias, et al.
Publicado: (2015)

Study of the polymorphisms of cyclooxygenase-2 (−765G>C) and 5-lipoxygenase (1708G>A) in patients with colorectal cancer
por: PIMENTA, CÉLIA APARECIDA MARQUES, et al.
Publicado: (2014)

Endocannabinoid Oxygenation by Cyclooxygenases, Lipoxygenases, and Cytochromes P450: Cross-Talk between the Eicosanoid and Endocannabinoid Signaling Pathways
por: Rouzer, Carol A., et al.
Publicado: (2011)

Role of Phytochemicals in Cancer Chemoprevention: Insights
por: George, Blassan P., et al.
Publicado: (2021)

Tetrahydrofurandiol Stimulation of Phospholipase A(2), Lipoxygenase, and Cyclooxygenase Gene Expression and MCF-7 Human Breast Cancer Cell Proliferation
por: Markaverich, Barry M., et al.
Publicado: (2007)

Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A(2), cyclooxygenases, lipoxygenase and pro-inflammatory cytokines
por: Jantan, Ibrahim, et al.
Publicado: (2014)

Dual Behavior of Long-Chain Fatty Acids and Their Cyclooxygenase/Lipoxygenase Metabolites on Human Intestinal Caco-2 Cell Growth
por: Storniolo, Carolina E., et al.
Publicado: (2020)

α-Conotoxins and α-Cobratoxin Promote, while Lipoxygenase and Cyclooxygenase Inhibitors Suppress the Proliferation of Glioma C6 Cells
por: Terpinskaya, Tatiana I., et al.
Publicado: (2021)

Biosynthetic Crossover of 5-Lipoxygenase and Cyclooxygenase-2 Yields 5-Hydroxy-PGE(2) and 5-Hydroxy-PGD(2)
por: Nakashima, Fumie, et al.
Publicado: (2021)

Dietary Polyphenols in Cancer Chemoprevention: Implications in Pancreatic Cancer
por: Thyagarajan, Anita, et al.
Publicado: (2020)

The Role of PPARγ Receptors and Leukotriene B(4) Receptors in Mediating the Effects of LY293111 in Pancreatic Cancer
por: Adrian, Thomas E., et al.
Publicado: (2008)

Zinc Oxide Nanoparticles Exhibit Both Cyclooxygenase- and Lipoxygenase-Mediated Apoptosis in Human Bone Marrow-Derived Mesenchymal Stem Cells
por: Kim, Dong-Yung, et al.
Publicado: (2019)

The 5-lipoxygenase/cyclooxygenase-2 cross-over metabolite, hemiketal E(2), enhances VEGFR2 activation and promotes angiogenesis
por: Nakashima, Fumie, et al.
Publicado: (2023)

Diclofenac derivatives as concomitant inhibitors of cholinesterase, monoamine oxidase, cyclooxygenase-2 and 5-lipoxygenase for the treatment of Alzheimer's disease: synthesis, pharmacology, toxicity and docking studies
por: Javed, Muhammad Aamir, et al.
Publicado: (2022)

Pancreatic Cancer: Molecular, Biochemical, Chemopreventive, and Therapeutic Aspects
por: Iovanna, Juan, et al.
Publicado: (2010)

Effect of ω-3 and ω-9 fatty acid rich oils on lipoxygenases and cyclooxygenases enzymes and on the growth of a mammary adenocarcinoma model
por: Comba, Andrea, et al.
Publicado: (2010)

The Effect of Omega-3 and Omega-6 Polyunsaturated Fatty Acids on the Production of Cyclooxygenase and Lipoxygenase Metabolites by Human Umbilical Vein Endothelial Cells
por: Araujo, Pedro, et al.
Publicado: (2019)

α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors
por: Osipov, Alexey V., et al.
Publicado: (2020)

Development of a quantitative proteomics approach for cyclooxygenases and lipoxygenases in parallel to quantitative oxylipin analysis allowing the comprehensive investigation of the arachidonic acid cascade
por: Hartung, Nicole M., et al.
Publicado: (2023)

Polymorphisms in Cyclooxygenase, Lipoxygenase, and TP53 Genes Predict Colorectal Polyp Risk Reduction by Aspirin in the seAFOod Polyp Prevention Trial
por: Davies, John R., et al.
Publicado: (2023)

Flavocoxid Inhibits Phospholipase A2, Peroxidase Moieties of the Cyclooxygenases (COX), and 5-Lipoxygenase, Modifies COX-2 Gene Expression, and Acts as an Antioxidant
por: Burnett, Bruce P., et al.
Publicado: (2011)

The Medicinal Timber Canarium patentinervium Miq. (Burseraceae Kunth.) Is an Anti-Inflammatory Bioresource of Dual Inhibitors of Cyclooxygenase (COX) and 5-Lipoxygenase (5-LOX)
por: Mogana, R., et al.
Publicado: (2013)

Cyclooxygenase in Cancer Prevention and Treatments for Actinic Keratosis
por: Thomas, Gareth J., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_e35jmg08hv771dfjk3r5f7do1i