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Apoptosis: Targets in Pancreatic Cancer
Pancreatic adenocarcinoma is characterized by poor prognosis, because of late diagnosis and lack of response to chemo- and/or radiation therapies. Resistance to apoptosis mainly causes this insensitivity to conventional therapies. Apoptosis or programmed cell death is a central regulator of tissue h...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2003
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC149420/ https://www.ncbi.nlm.nih.gov/pubmed/12605713 http://dx.doi.org/10.1186/1476-4598-2-6 |
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author | Westphal, Sabine Kalthoff, Holger |
author_facet | Westphal, Sabine Kalthoff, Holger |
author_sort | Westphal, Sabine |
collection | PubMed |
description | Pancreatic adenocarcinoma is characterized by poor prognosis, because of late diagnosis and lack of response to chemo- and/or radiation therapies. Resistance to apoptosis mainly causes this insensitivity to conventional therapies. Apoptosis or programmed cell death is a central regulator of tissue homeostasis. Certain genetic disturbances of apoptotic signaling pathways have been found in carcinomas leading to tumor development and progression. In the past few years, the knowledge about the complex pathways of apoptosis has strongly increased and new therapeutic approaches based on this knowledge are being developed. This review will focus on the role of apoptotic proteins contributing to pancreatic cancer development and progression and will demonstrate possible targets to influence this deadly disease. |
format | Text |
id | pubmed-149420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-1494202003-02-25 Apoptosis: Targets in Pancreatic Cancer Westphal, Sabine Kalthoff, Holger Mol Cancer Review Pancreatic adenocarcinoma is characterized by poor prognosis, because of late diagnosis and lack of response to chemo- and/or radiation therapies. Resistance to apoptosis mainly causes this insensitivity to conventional therapies. Apoptosis or programmed cell death is a central regulator of tissue homeostasis. Certain genetic disturbances of apoptotic signaling pathways have been found in carcinomas leading to tumor development and progression. In the past few years, the knowledge about the complex pathways of apoptosis has strongly increased and new therapeutic approaches based on this knowledge are being developed. This review will focus on the role of apoptotic proteins contributing to pancreatic cancer development and progression and will demonstrate possible targets to influence this deadly disease. BioMed Central 2003-01-07 /pmc/articles/PMC149420/ /pubmed/12605713 http://dx.doi.org/10.1186/1476-4598-2-6 Text en Copyright © 2003 Westphal and Kalthoff; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
spellingShingle | Review Westphal, Sabine Kalthoff, Holger Apoptosis: Targets in Pancreatic Cancer |
title | Apoptosis: Targets in Pancreatic Cancer |
title_full | Apoptosis: Targets in Pancreatic Cancer |
title_fullStr | Apoptosis: Targets in Pancreatic Cancer |
title_full_unstemmed | Apoptosis: Targets in Pancreatic Cancer |
title_short | Apoptosis: Targets in Pancreatic Cancer |
title_sort | apoptosis: targets in pancreatic cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC149420/ https://www.ncbi.nlm.nih.gov/pubmed/12605713 http://dx.doi.org/10.1186/1476-4598-2-6 |
work_keys_str_mv | AT westphalsabine apoptosistargetsinpancreaticcancer AT kalthoffholger apoptosistargetsinpancreaticcancer |