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The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi

In this review we will focus on the current status and views concerning the production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi. We will focus on single-chain antibody fragment production (scFv and V(HH)) by these lower eukaryotes and the possible applicatio...

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Detalles Bibliográficos
Autores principales: Joosten, Vivi, Lokman, Christien, van den Hondel, Cees AMJJ, Punt, Peter J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC149433/
https://www.ncbi.nlm.nih.gov/pubmed/12605725
http://dx.doi.org/10.1186/1475-2859-2-1
Descripción
Sumario:In this review we will focus on the current status and views concerning the production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi. We will focus on single-chain antibody fragment production (scFv and V(HH)) by these lower eukaryotes and the possible applications of these proteins. Also the coupling of fragments to relevant enzymes or other components will be discussed. As an example of the fusion protein strategy, the 'magic bullet' approach for industrial applications, will be highlighted.