The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi

In this review we will focus on the current status and views concerning the production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi. We will focus on single-chain antibody fragment production (scFv and V(HH)) by these lower eukaryotes and the possible applicatio...

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Detalles Bibliográficos
Autores principales: Joosten, Vivi, Lokman, Christien, van den Hondel, Cees AMJJ, Punt, Peter J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC149433/
https://www.ncbi.nlm.nih.gov/pubmed/12605725
http://dx.doi.org/10.1186/1475-2859-2-1
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author Joosten, Vivi
Lokman, Christien
van den Hondel, Cees AMJJ
Punt, Peter J
author_facet Joosten, Vivi
Lokman, Christien
van den Hondel, Cees AMJJ
Punt, Peter J
author_sort Joosten, Vivi
collection PubMed
description In this review we will focus on the current status and views concerning the production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi. We will focus on single-chain antibody fragment production (scFv and V(HH)) by these lower eukaryotes and the possible applications of these proteins. Also the coupling of fragments to relevant enzymes or other components will be discussed. As an example of the fusion protein strategy, the 'magic bullet' approach for industrial applications, will be highlighted.
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spelling pubmed-1494332003-02-25 The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi Joosten, Vivi Lokman, Christien van den Hondel, Cees AMJJ Punt, Peter J Microb Cell Fact Review In this review we will focus on the current status and views concerning the production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi. We will focus on single-chain antibody fragment production (scFv and V(HH)) by these lower eukaryotes and the possible applications of these proteins. Also the coupling of fragments to relevant enzymes or other components will be discussed. As an example of the fusion protein strategy, the 'magic bullet' approach for industrial applications, will be highlighted. BioMed Central 2003-01-30 /pmc/articles/PMC149433/ /pubmed/12605725 http://dx.doi.org/10.1186/1475-2859-2-1 Text en Copyright © 2003 Joosten et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Review
Joosten, Vivi
Lokman, Christien
van den Hondel, Cees AMJJ
Punt, Peter J
The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi
title The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi
title_full The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi
title_fullStr The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi
title_full_unstemmed The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi
title_short The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi
title_sort production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC149433/
https://www.ncbi.nlm.nih.gov/pubmed/12605725
http://dx.doi.org/10.1186/1475-2859-2-1
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