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Evolutionary and Physiological Importance of Hub Proteins

It has been claimed that proteins with more interaction partners (hubs) are both physiologically more important (i.e., less dispensable) and, owing to an assumed high density of binding sites, slow evolving. Not all analyses, however, support these results, probably because of biased and less-than r...

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Detalles Bibliográficos
Autores principales: Batada, Nizar N, Hurst, Laurence D, Tyers, Mike
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1500817/
https://www.ncbi.nlm.nih.gov/pubmed/16839197
http://dx.doi.org/10.1371/journal.pcbi.0020088