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Locked nucleoside analogues expand the potential of DNAzymes to cleave structured RNA targets
BACKGROUND: DNAzymes cleave at predetermined sequences within RNA. A prerequisite for cleavage is that the DNAzyme can gain access to its target, and thus the DNAzyme must be capable of unfolding higher-order structures that are present in the RNA substrate. However, in many cases the RNA target seq...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1501032/ https://www.ncbi.nlm.nih.gov/pubmed/16753066 http://dx.doi.org/10.1186/1471-2199-7-19 |