Intraluminal instillation of urokinase and autologous plasma: a method to unblock occluded central venous ports

BACKGROUND: Therapeutic use and effective function of recombinant urokinase (r-UK) for occluded ports need the presence of plasminogen. METHODS: As a therapeutic proof of principle, we demonstrate that the use of r-UK and autologous plasma effectively reestablishes the function of occluded central v...

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Detalles Bibliográficos
Autores principales: Seifert, Georg, Riess, Hanno, Seeger, Karl, Henze, Guenter, Borgmann, Anja
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1501039/
https://www.ncbi.nlm.nih.gov/pubmed/16635269
http://dx.doi.org/10.1186/1471-2407-6-103
Descripción
Sumario:BACKGROUND: Therapeutic use and effective function of recombinant urokinase (r-UK) for occluded ports need the presence of plasminogen. METHODS: As a therapeutic proof of principle, we demonstrate that the use of r-UK and autologous plasma effectively reestablishes the function of occluded central venous ports (CVP) resistant to routine management of catheter occlusion. Five patients with occluded ports resistant to the routine management were treated. RESULTS: All patients were successfully treated with thrombolytic therapy using intraluminal instillation of r-UK and autologous plasma. CONCLUSION: Instillation of r-UK and autologous plasma is a safe and effective method for management of CVP occlusion.

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