Intraluminal instillation of urokinase and autologous plasma: a method to unblock occluded central venous ports

BACKGROUND: Therapeutic use and effective function of recombinant urokinase (r-UK) for occluded ports need the presence of plasminogen. METHODS: As a therapeutic proof of principle, we demonstrate that the use of r-UK and autologous plasma effectively reestablishes the function of occluded central v...

Descripción completa

Detalles Bibliográficos
Autores principales: Seifert, Georg, Riess, Hanno, Seeger, Karl, Henze, Guenter, Borgmann, Anja
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1501039/
https://www.ncbi.nlm.nih.gov/pubmed/16635269
http://dx.doi.org/10.1186/1471-2407-6-103
_version_ 1782128395957567488
author Seifert, Georg
Riess, Hanno
Seeger, Karl
Henze, Guenter
Borgmann, Anja
author_facet Seifert, Georg
Riess, Hanno
Seeger, Karl
Henze, Guenter
Borgmann, Anja
author_sort Seifert, Georg
collection PubMed
description BACKGROUND: Therapeutic use and effective function of recombinant urokinase (r-UK) for occluded ports need the presence of plasminogen. METHODS: As a therapeutic proof of principle, we demonstrate that the use of r-UK and autologous plasma effectively reestablishes the function of occluded central venous ports (CVP) resistant to routine management of catheter occlusion. Five patients with occluded ports resistant to the routine management were treated. RESULTS: All patients were successfully treated with thrombolytic therapy using intraluminal instillation of r-UK and autologous plasma. CONCLUSION: Instillation of r-UK and autologous plasma is a safe and effective method for management of CVP occlusion.
format Text
id pubmed-1501039
institution National Center for Biotechnology Information
language English
publishDate 2006
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-15010392006-07-13 Intraluminal instillation of urokinase and autologous plasma: a method to unblock occluded central venous ports Seifert, Georg Riess, Hanno Seeger, Karl Henze, Guenter Borgmann, Anja BMC Cancer Technical Advance BACKGROUND: Therapeutic use and effective function of recombinant urokinase (r-UK) for occluded ports need the presence of plasminogen. METHODS: As a therapeutic proof of principle, we demonstrate that the use of r-UK and autologous plasma effectively reestablishes the function of occluded central venous ports (CVP) resistant to routine management of catheter occlusion. Five patients with occluded ports resistant to the routine management were treated. RESULTS: All patients were successfully treated with thrombolytic therapy using intraluminal instillation of r-UK and autologous plasma. CONCLUSION: Instillation of r-UK and autologous plasma is a safe and effective method for management of CVP occlusion. BioMed Central 2006-04-24 /pmc/articles/PMC1501039/ /pubmed/16635269 http://dx.doi.org/10.1186/1471-2407-6-103 Text en Copyright © 2006 Seifert et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Technical Advance
Seifert, Georg
Riess, Hanno
Seeger, Karl
Henze, Guenter
Borgmann, Anja
Intraluminal instillation of urokinase and autologous plasma: a method to unblock occluded central venous ports
title Intraluminal instillation of urokinase and autologous plasma: a method to unblock occluded central venous ports
title_full Intraluminal instillation of urokinase and autologous plasma: a method to unblock occluded central venous ports
title_fullStr Intraluminal instillation of urokinase and autologous plasma: a method to unblock occluded central venous ports
title_full_unstemmed Intraluminal instillation of urokinase and autologous plasma: a method to unblock occluded central venous ports
title_short Intraluminal instillation of urokinase and autologous plasma: a method to unblock occluded central venous ports
title_sort intraluminal instillation of urokinase and autologous plasma: a method to unblock occluded central venous ports
topic Technical Advance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1501039/
https://www.ncbi.nlm.nih.gov/pubmed/16635269
http://dx.doi.org/10.1186/1471-2407-6-103
work_keys_str_mv AT seifertgeorg intraluminalinstillationofurokinaseandautologousplasmaamethodtounblockoccludedcentralvenousports
AT riesshanno intraluminalinstillationofurokinaseandautologousplasmaamethodtounblockoccludedcentralvenousports
AT seegerkarl intraluminalinstillationofurokinaseandautologousplasmaamethodtounblockoccludedcentralvenousports
AT henzeguenter intraluminalinstillationofurokinaseandautologousplasmaamethodtounblockoccludedcentralvenousports
AT borgmannanja intraluminalinstillationofurokinaseandautologousplasmaamethodtounblockoccludedcentralvenousports

Ejemplares similares